FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988748783> ?p ?o ?g. }

• W1988748783 endingPage "2046" @default.
• W1988748783 startingPage "2038" @default.
• W1988748783 abstract "Breast cancer micrometastases in the bone marrow are resistant to chemotherapy. They can remain dormant for years before some begin to proliferate. We seek to understand survival mechanisms and develop targeted approaches to eliminating these cells.In an in vitro model of dormancy, basic fibroblast growth factor 2 (FGF-2), abundant in the bone marrow, inhibits the growth of well-differentiated cells in the 2- to 10-cell stage and up-regulates integrin alpha(5)beta(1). Through this integrin, cells bind fibronectin, spread out, and acquire a survival advantage, partly through activation of the phosphatidylinositol 3-kinase/Akt pathway. We investigated the effects of Taxotere, flavopiridol, and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and p38 inhibitors on survival of dormant clones and that of flavopiridol on expression of integrins, adhesion strength, and phosphorylation of Akt, ERK 1/2, and p38.Dormant MCF-7 and T-47D cell clones were resistant to Taxotere concentrations 10-fold higher than needed to eliminate growing clones but were almost completely eradicated by 200 nmol/L flavopiridol. Flavopiridol caused a decrease in FGF-2-induced expression of integrins, including alpha(5) and beta(1), and decreased FGF-2-induced specific adhesion to fibronectin. It diminished Akt phosphorylation, but reexpression of active Akt was not sufficient to reverse dormant clone inhibition. Flavopiridol did not affect phosphorylation of ERK 1/2 and p38 but diminished total protein levels. Chemical inhibition of these pathways partially abrogated dormant clone survival.Flavopiridol has pleiotropic effects on key targets involved with survival of dormant breast cancer cells and may represent a useful approach to eliminating cells dependent on multiple signal pathways for survival." @default.
• W1988748783 created "2016-06-24" @default.
• W1988748783 creator A5019301771 @default.
• W1988748783 creator A5023748809 @default.
• W1988748783 creator A5053615282 @default.
• W1988748783 creator A5075040626 @default.
• W1988748783 creator A5080243525 @default.
• W1988748783 date "2005-03-01" @default.
• W1988748783 modified "2023-09-24" @default.
• W1988748783 title "Flavopiridol Blocks Integrin-Mediated Survival in Dormant Breast Cancer Cells" @default.
• W1988748783 cites W1611726375 @default.
• W1988748783 cites W1980656099 @default.
• W1988748783 cites W1986509532 @default.
• W1988748783 cites W2014328592 @default.
• W1988748783 cites W2016987929 @default.
• W1988748783 cites W2024571011 @default.
• W1988748783 cites W2030245411 @default.
• W1988748783 cites W2035023695 @default.
• W1988748783 cites W2035038987 @default.
• W1988748783 cites W2038894733 @default.
• W1988748783 cites W2057046543 @default.
• W1988748783 cites W2059887278 @default.
• W1988748783 cites W2061063120 @default.
• W1988748783 cites W2079084987 @default.
• W1988748783 cites W2081567150 @default.
• W1988748783 cites W2082402654 @default.
• W1988748783 cites W2083743116 @default.
• W1988748783 cites W2085319638 @default.
• W1988748783 cites W2086056059 @default.
• W1988748783 cites W2105480046 @default.
• W1988748783 cites W2111414495 @default.
• W1988748783 cites W2141972206 @default.
• W1988748783 cites W2144229881 @default.
• W1988748783 cites W2144240156 @default.
• W1988748783 cites W2147840403 @default.
• W1988748783 cites W2153053825 @default.
• W1988748783 cites W2154994717 @default.
• W1988748783 cites W2271721498 @default.
• W1988748783 cites W2321753125 @default.
• W1988748783 doi "https://doi.org/10.1158/1078-0432.ccr-04-1083" @default.
• W1988748783 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15756030" @default.
• W1988748783 hasPublicationYear "2005" @default.
• W1988748783 type Work @default.
• W1988748783 sameAs 1988748783 @default.
• W1988748783 citedByCount "32" @default.
• W1988748783 countsByYear W19887487832013 @default.
• W1988748783 countsByYear W19887487832015 @default.
• W1988748783 countsByYear W19887487832016 @default.
• W1988748783 countsByYear W19887487832017 @default.
• W1988748783 countsByYear W19887487832018 @default.
• W1988748783 countsByYear W19887487832019 @default.
• W1988748783 countsByYear W19887487832020 @default.
• W1988748783 countsByYear W19887487832021 @default.
• W1988748783 countsByYear W19887487832022 @default.
• W1988748783 countsByYear W19887487832023 @default.
• W1988748783 crossrefType "journal-article" @default.
• W1988748783 hasAuthorship W1988748783A5019301771 @default.
• W1988748783 hasAuthorship W1988748783A5023748809 @default.
• W1988748783 hasAuthorship W1988748783A5053615282 @default.
• W1988748783 hasAuthorship W1988748783A5075040626 @default.
• W1988748783 hasAuthorship W1988748783A5080243525 @default.
• W1988748783 hasConcept C11960822 @default.
• W1988748783 hasConcept C1491633281 @default.
• W1988748783 hasConcept C184235292 @default.
• W1988748783 hasConcept C189165786 @default.
• W1988748783 hasConcept C195687474 @default.
• W1988748783 hasConcept C502942594 @default.
• W1988748783 hasConcept C552990157 @default.
• W1988748783 hasConcept C55493867 @default.
• W1988748783 hasConcept C57074206 @default.
• W1988748783 hasConcept C62478195 @default.
• W1988748783 hasConcept C75217442 @default.
• W1988748783 hasConcept C81089528 @default.
• W1988748783 hasConcept C86492073 @default.
• W1988748783 hasConcept C86554907 @default.
• W1988748783 hasConcept C86803240 @default.
• W1988748783 hasConcept C95444343 @default.
• W1988748783 hasConceptScore W1988748783C11960822 @default.
• W1988748783 hasConceptScore W1988748783C1491633281 @default.
• W1988748783 hasConceptScore W1988748783C184235292 @default.
• W1988748783 hasConceptScore W1988748783C189165786 @default.
• W1988748783 hasConceptScore W1988748783C195687474 @default.
• W1988748783 hasConceptScore W1988748783C502942594 @default.
• W1988748783 hasConceptScore W1988748783C552990157 @default.
• W1988748783 hasConceptScore W1988748783C55493867 @default.
• W1988748783 hasConceptScore W1988748783C57074206 @default.
• W1988748783 hasConceptScore W1988748783C62478195 @default.
• W1988748783 hasConceptScore W1988748783C75217442 @default.
• W1988748783 hasConceptScore W1988748783C81089528 @default.
• W1988748783 hasConceptScore W1988748783C86492073 @default.
• W1988748783 hasConceptScore W1988748783C86554907 @default.
• W1988748783 hasConceptScore W1988748783C86803240 @default.
• W1988748783 hasConceptScore W1988748783C95444343 @default.
• W1988748783 hasIssue "5" @default.
• W1988748783 hasLocation W19887487831 @default.
• W1988748783 hasLocation W19887487832 @default.
• W1988748783 hasOpenAccess W1988748783 @default.
• W1988748783 hasPrimaryLocation W19887487831 @default.

• next