Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988757002> ?p ?o ?g. }
- W1988757002 endingPage "1133" @default.
- W1988757002 startingPage "1125" @default.
- W1988757002 abstract "The proto-oncogene product gp 140prototrk (TrkA) is the receptor tyrosine kinase that mediates nerve growth factor-induced neuronal survival and differentiation. In receptor tyrosine kinases, specific intracellular tyrosine residues become phosphorylated after ligand binding and the phosphorylated tyrosines induce the cascade of signal transduction. Here we have identified intracellular tyrosine residues of TrkA involved in nerve growth factor-induced neurite outgrowth of PC12 cells, using site-directed mutagenesis and a PC12 cell line expressing very low levels of endogenous TrkA (PC12nnr5 cells). We analysed eight conserved intracellular tyrosine residues of TrkA while the three putative autophosphorylation sites conferring tyrosine kinase activity were left intact. Five tyrosine residues, Y499, Y643, Y704, Y760 and Y794, in rat TrkA were involved in nerve growth factor-induced neurite outgrowth. None of these tyrosines mediated the full activity of wild-type TrkA, and a pair of these tyrosines, Y760 and Y794, promoted neurite outgrowth in an additive manner. These data indicate that no single tyrosine is sufficient to induce complete neurite outgrowth but the five tyrosine residues Y499, Y643, Y704, Y760 and Y794 cooperate to exhibit the full activity of wild-type TrkA." @default.
- W1988757002 created "2016-06-24" @default.
- W1988757002 creator A5001690399 @default.
- W1988757002 creator A5058229542 @default.
- W1988757002 creator A5078359227 @default.
- W1988757002 date "1995-06-01" @default.
- W1988757002 modified "2023-09-26" @default.
- W1988757002 title "TrkA Tyrosine Residues Involved in NGF-induced Neurite Outgrowth of PC12 Cells" @default.
- W1988757002 cites W1501666754 @default.
- W1988757002 cites W1545168616 @default.
- W1988757002 cites W1572716768 @default.
- W1988757002 cites W1576886106 @default.
- W1988757002 cites W1595498439 @default.
- W1988757002 cites W1630763432 @default.
- W1988757002 cites W1795056021 @default.
- W1988757002 cites W1863695472 @default.
- W1988757002 cites W1892433039 @default.
- W1988757002 cites W1964377967 @default.
- W1988757002 cites W1971475788 @default.
- W1988757002 cites W1974517994 @default.
- W1988757002 cites W1975260251 @default.
- W1988757002 cites W1978274895 @default.
- W1988757002 cites W198779817 @default.
- W1988757002 cites W1990216950 @default.
- W1988757002 cites W2000079550 @default.
- W1988757002 cites W2000269495 @default.
- W1988757002 cites W2001163784 @default.
- W1988757002 cites W2005529016 @default.
- W1988757002 cites W2007796735 @default.
- W1988757002 cites W2008333101 @default.
- W1988757002 cites W2010488494 @default.
- W1988757002 cites W2010886707 @default.
- W1988757002 cites W2011543201 @default.
- W1988757002 cites W2014677270 @default.
- W1988757002 cites W2015802650 @default.
- W1988757002 cites W2020244870 @default.
- W1988757002 cites W2020333978 @default.
- W1988757002 cites W2020537787 @default.
- W1988757002 cites W2023142792 @default.
- W1988757002 cites W2027854877 @default.
- W1988757002 cites W2030156849 @default.
- W1988757002 cites W2030213176 @default.
- W1988757002 cites W2037831105 @default.
- W1988757002 cites W2038816853 @default.
- W1988757002 cites W2040620685 @default.
- W1988757002 cites W2041190857 @default.
- W1988757002 cites W2059925029 @default.
- W1988757002 cites W2063695629 @default.
- W1988757002 cites W2066790769 @default.
- W1988757002 cites W2069132844 @default.
- W1988757002 cites W2069748621 @default.
- W1988757002 cites W2074659620 @default.
- W1988757002 cites W2074969533 @default.
- W1988757002 cites W2083612840 @default.
- W1988757002 cites W2091309613 @default.
- W1988757002 cites W2091659591 @default.
- W1988757002 cites W2099808976 @default.
- W1988757002 cites W2150228169 @default.
- W1988757002 cites W2207963001 @default.
- W1988757002 cites W74885494 @default.
- W1988757002 cites W97763042 @default.
- W1988757002 doi "https://doi.org/10.1111/j.1460-9568.1995.tb01102.x" @default.
- W1988757002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7582085" @default.
- W1988757002 hasPublicationYear "1995" @default.
- W1988757002 type Work @default.
- W1988757002 sameAs 1988757002 @default.
- W1988757002 citedByCount "49" @default.
- W1988757002 countsByYear W19887570022013 @default.
- W1988757002 countsByYear W19887570022014 @default.
- W1988757002 countsByYear W19887570022015 @default.
- W1988757002 countsByYear W19887570022017 @default.
- W1988757002 countsByYear W19887570022018 @default.
- W1988757002 countsByYear W19887570022019 @default.
- W1988757002 countsByYear W19887570022020 @default.
- W1988757002 countsByYear W19887570022022 @default.
- W1988757002 crossrefType "journal-article" @default.
- W1988757002 hasAuthorship W1988757002A5001690399 @default.
- W1988757002 hasAuthorship W1988757002A5058229542 @default.
- W1988757002 hasAuthorship W1988757002A5078359227 @default.
- W1988757002 hasConcept C101544691 @default.
- W1988757002 hasConcept C113246987 @default.
- W1988757002 hasConcept C11960822 @default.
- W1988757002 hasConcept C134139212 @default.
- W1988757002 hasConcept C150109051 @default.
- W1988757002 hasConcept C170493617 @default.
- W1988757002 hasConcept C171034665 @default.
- W1988757002 hasConcept C180361614 @default.
- W1988757002 hasConcept C185592680 @default.
- W1988757002 hasConcept C202751555 @default.
- W1988757002 hasConcept C23440912 @default.
- W1988757002 hasConcept C2775960820 @default.
- W1988757002 hasConcept C2776165026 @default.
- W1988757002 hasConcept C2777553839 @default.
- W1988757002 hasConcept C2778423431 @default.
- W1988757002 hasConcept C42362537 @default.
- W1988757002 hasConcept C55493867 @default.
- W1988757002 hasConcept C56703729 @default.
- W1988757002 hasConcept C62478195 @default.