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- W1988757966 abstract "The role of genetics in determining life-span is complex and paradoxical. Although the heritability of life-span is relatively minor, some genetic variants significantly modify senescence of mammals and invertebrates, with both positive and negative impacts on age-related disorders and life-spans. In certain examples, the gene variants alter metabolic pathways, which could thereby mediate interactions with nutritional and other environmental factors that influence life-span. Given the relatively minor effect and variable penetrance of genetic risk factors that appear to affect survival and health at advanced ages, life-style and other environmental influences may profoundly modify outcomes of aging." @default.
- W1988757966 created "2016-06-24" @default.
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- W1988757966 date "1997-10-17" @default.
- W1988757966 modified "2023-10-02" @default.
- W1988757966 title "Genetics of Aging" @default.
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- W1988757966 doi "https://doi.org/10.1126/science.278.5337.407" @default.
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