FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988758329> ?p ?o ?g. }

• W1988758329 endingPage "699" @default.
• W1988758329 startingPage "694" @default.
• W1988758329 abstract "Accurate transcription is an essential step in maintaining genetic information. Error-prone transcription has been proposed to contribute to cancer, aging, adaptive mutagenesis, and mutagenic evolution of retroviruses and retrotransposons. The mechanisms controlling transcription fidelity and the biological consequences of transcription errors are poorly understood. Because of the transient nature of mRNAs and the lack of reliable experimental systems, the identification and characterization of defects that increase transcription errors have been particularly challenging. In this review we describe novel genetic screens for the isolation of fidelity mutants in both Saccharomyces cerevisiae and Escherichia coli RNA polymerases. We obtained and characterized two distinct classes of mutants altering NTP misincorporation and transcription slippage both in vivo and in vitro. Our study not only validates the genetic schemes for the isolation of RNA polymerase mutants that alter fidelity, but also sheds light on the mechanism of transcription accuracy. This article is part of a Special Issue entitled: Chromatin in time and space." @default.
• W1988758329 created "2016-06-24" @default.
• W1988758329 creator A5004678270 @default.
• W1988758329 creator A5026007018 @default.
• W1988758329 creator A5039631216 @default.
• W1988758329 creator A5086553695 @default.
• W1988758329 date "2012-07-01" @default.
• W1988758329 modified "2023-10-05" @default.
• W1988758329 title "Isolation and characterization of transcription fidelity mutants" @default.
• W1988758329 cites W1500096282 @default.
• W1988758329 cites W1514932602 @default.
• W1988758329 cites W1590546489 @default.
• W1988758329 cites W1968302884 @default.
• W1988758329 cites W1972597018 @default.
• W1988758329 cites W1983796128 @default.
• W1988758329 cites W1994342611 @default.
• W1988758329 cites W1994350816 @default.
• W1988758329 cites W1994801641 @default.
• W1988758329 cites W2002957811 @default.
• W1988758329 cites W2017990250 @default.
• W1988758329 cites W2032619610 @default.
• W1988758329 cites W2038211892 @default.
• W1988758329 cites W2078784388 @default.
• W1988758329 cites W2083893624 @default.
• W1988758329 cites W2098122641 @default.
• W1988758329 cites W2115623690 @default.
• W1988758329 cites W2142618175 @default.
• W1988758329 cites W2146449823 @default.
• W1988758329 cites W2153023603 @default.
• W1988758329 cites W2156018224 @default.
• W1988758329 cites W2158787064 @default.
• W1988758329 cites W2163748720 @default.
• W1988758329 cites W3145335483 @default.
• W1988758329 doi "https://doi.org/10.1016/j.bbagrm.2012.02.005" @default.
• W1988758329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7511983" @default.
• W1988758329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22366339" @default.
• W1988758329 hasPublicationYear "2012" @default.
• W1988758329 type Work @default.
• W1988758329 sameAs 1988758329 @default.
• W1988758329 citedByCount "35" @default.
• W1988758329 countsByYear W19887583292012 @default.
• W1988758329 countsByYear W19887583292013 @default.
• W1988758329 countsByYear W19887583292014 @default.
• W1988758329 countsByYear W19887583292015 @default.
• W1988758329 countsByYear W19887583292016 @default.
• W1988758329 countsByYear W19887583292017 @default.
• W1988758329 countsByYear W19887583292018 @default.
• W1988758329 countsByYear W19887583292019 @default.
• W1988758329 countsByYear W19887583292020 @default.
• W1988758329 countsByYear W19887583292021 @default.
• W1988758329 countsByYear W19887583292022 @default.
• W1988758329 countsByYear W19887583292023 @default.
• W1988758329 crossrefType "journal-article" @default.
• W1988758329 hasAuthorship W1988758329A5004678270 @default.
• W1988758329 hasAuthorship W1988758329A5026007018 @default.
• W1988758329 hasAuthorship W1988758329A5039631216 @default.
• W1988758329 hasAuthorship W1988758329A5086553695 @default.
• W1988758329 hasBestOaLocation W19887583292 @default.
• W1988758329 hasConcept C101762097 @default.
• W1988758329 hasConcept C104317684 @default.
• W1988758329 hasConcept C138885662 @default.
• W1988758329 hasConcept C143065580 @default.
• W1988758329 hasConcept C144825837 @default.
• W1988758329 hasConcept C150194340 @default.
• W1988758329 hasConcept C179926584 @default.
• W1988758329 hasConcept C2776449523 @default.
• W1988758329 hasConcept C41895202 @default.
• W1988758329 hasConcept C54355233 @default.
• W1988758329 hasConcept C552990157 @default.
• W1988758329 hasConcept C64350747 @default.
• W1988758329 hasConcept C67705224 @default.
• W1988758329 hasConcept C70721500 @default.
• W1988758329 hasConcept C82381507 @default.
• W1988758329 hasConcept C83640560 @default.
• W1988758329 hasConcept C86803240 @default.
• W1988758329 hasConcept C95444343 @default.
• W1988758329 hasConceptScore W1988758329C101762097 @default.
• W1988758329 hasConceptScore W1988758329C104317684 @default.
• W1988758329 hasConceptScore W1988758329C138885662 @default.
• W1988758329 hasConceptScore W1988758329C143065580 @default.
• W1988758329 hasConceptScore W1988758329C144825837 @default.
• W1988758329 hasConceptScore W1988758329C150194340 @default.
• W1988758329 hasConceptScore W1988758329C179926584 @default.
• W1988758329 hasConceptScore W1988758329C2776449523 @default.
• W1988758329 hasConceptScore W1988758329C41895202 @default.
• W1988758329 hasConceptScore W1988758329C54355233 @default.
• W1988758329 hasConceptScore W1988758329C552990157 @default.
• W1988758329 hasConceptScore W1988758329C64350747 @default.
• W1988758329 hasConceptScore W1988758329C67705224 @default.
• W1988758329 hasConceptScore W1988758329C70721500 @default.
• W1988758329 hasConceptScore W1988758329C82381507 @default.
• W1988758329 hasConceptScore W1988758329C83640560 @default.
• W1988758329 hasConceptScore W1988758329C86803240 @default.
• W1988758329 hasConceptScore W1988758329C95444343 @default.
• W1988758329 hasIssue "7" @default.
• W1988758329 hasLocation W19887583291 @default.
• W1988758329 hasLocation W19887583292 @default.
• W1988758329 hasLocation W19887583293 @default.

• next