FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988762859> ?p ?o ?g. }

• W1988762859 endingPage "8659" @default.
• W1988762859 startingPage "8655" @default.
• W1988762859 abstract "Cdk-interacting protein 1 (Cip1) is a p53-regulated 21-kDa protein that inhibits several members of the cyclin-dependent kinase (CDK) family. It was initially observed in complexes containing CDK4, cyclin D, and proliferating cell nuclear antigen (PCNA). PCNA, in conjunction with activator 1, acts as a processivity factor for eukaryotic DNA polymerase (pol) delta, and these three proteins constitute the pol delta holoenzyme. In this report, we demonstrate that Cip1 can also directly inhibit DNA synthesis in vitro by binding to PCNA. Cip1 efficiently inhibits simian virus 40 replication dependent upon pol alpha, activator 1, PCNA, and pol delta, and this inhibition can be overcome by additional PCNA. Simian virus 40 DNA replication, catalyzed solely by high levels of pol alpha-primase complex, is unaffected by Cip1. Using the surface plasmon resonance technique, a direct physical interaction of PCNA and Cip1 was detected. We have observed that Cip1 efficiently inhibits synthesis of long (7.2 kb) but not short (10 nt) templates, suggesting that its association with PCNA is likely to impair the processive movement of pol delta during DNA chain elongation, as opposed to blocking assembly of the pol delta holoenzyme. The implications of the Cip1-PCNA interaction with respect to regulation of DNA synthesis, cell cycle checkpoint control, and DNA repair are discussed." @default.
• W1988762859 created "2016-06-24" @default.
• W1988762859 creator A5012521243 @default.
• W1988762859 creator A5025914907 @default.
• W1988762859 creator A5026830739 @default.
• W1988762859 creator A5030497198 @default.
• W1988762859 creator A5031987061 @default.
• W1988762859 creator A5054494155 @default.
• W1988762859 creator A5056717418 @default.
• W1988762859 creator A5067364412 @default.
• W1988762859 date "1994-08-30" @default.
• W1988762859 modified "2023-10-13" @default.
• W1988762859 title "Cdk-interacting protein 1 directly binds with proliferating cell nuclear antigen and inhibits DNA replication catalyzed by the DNA polymerase delta holoenzyme." @default.
• W1988762859 cites W1492751534 @default.
• W1988762859 cites W1517952165 @default.
• W1988762859 cites W1518359286 @default.
• W1988762859 cites W1540214411 @default.
• W1988762859 cites W1551254087 @default.
• W1988762859 cites W1559981481 @default.
• W1988762859 cites W1574197136 @default.
• W1988762859 cites W1580231709 @default.
• W1988762859 cites W1587273245 @default.
• W1988762859 cites W1608564947 @default.
• W1988762859 cites W1858390492 @default.
• W1988762859 cites W1977299280 @default.
• W1988762859 cites W1996413533 @default.
• W1988762859 cites W2012863320 @default.
• W1988762859 cites W2015519364 @default.
• W1988762859 cites W2058525130 @default.
• W1988762859 cites W2060063448 @default.
• W1988762859 cites W2065014822 @default.
• W1988762859 cites W2065480580 @default.
• W1988762859 cites W2070061120 @default.
• W1988762859 cites W2079718256 @default.
• W1988762859 cites W2089218510 @default.
• W1988762859 cites W2092713502 @default.
• W1988762859 cites W2108402398 @default.
• W1988762859 cites W2135535670 @default.
• W1988762859 cites W2135890914 @default.
• W1988762859 cites W2163864783 @default.
• W1988762859 cites W2171367003 @default.
• W1988762859 doi "https://doi.org/10.1073/pnas.91.18.8655" @default.
• W1988762859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/44665" @default.
• W1988762859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7915843" @default.
• W1988762859 hasPublicationYear "1994" @default.
• W1988762859 type Work @default.
• W1988762859 sameAs 1988762859 @default.
• W1988762859 citedByCount "397" @default.
• W1988762859 countsByYear W19887628592012 @default.
• W1988762859 countsByYear W19887628592013 @default.
• W1988762859 countsByYear W19887628592014 @default.
• W1988762859 countsByYear W19887628592015 @default.
• W1988762859 countsByYear W19887628592016 @default.
• W1988762859 countsByYear W19887628592017 @default.
• W1988762859 countsByYear W19887628592018 @default.
• W1988762859 countsByYear W19887628592019 @default.
• W1988762859 countsByYear W19887628592020 @default.
• W1988762859 countsByYear W19887628592022 @default.
• W1988762859 crossrefType "journal-article" @default.
• W1988762859 hasAuthorship W1988762859A5012521243 @default.
• W1988762859 hasAuthorship W1988762859A5025914907 @default.
• W1988762859 hasAuthorship W1988762859A5026830739 @default.
• W1988762859 hasAuthorship W1988762859A5030497198 @default.
• W1988762859 hasAuthorship W1988762859A5031987061 @default.
• W1988762859 hasAuthorship W1988762859A5054494155 @default.
• W1988762859 hasAuthorship W1988762859A5056717418 @default.
• W1988762859 hasAuthorship W1988762859A5067364412 @default.
• W1988762859 hasBestOaLocation W19887628592 @default.
• W1988762859 hasConcept C104317684 @default.
• W1988762859 hasConcept C104690221 @default.
• W1988762859 hasConcept C131140672 @default.
• W1988762859 hasConcept C151158763 @default.
• W1988762859 hasConcept C153911025 @default.
• W1988762859 hasConcept C156719811 @default.
• W1988762859 hasConcept C188036394 @default.
• W1988762859 hasConcept C2756471 @default.
• W1988762859 hasConcept C31254050 @default.
• W1988762859 hasConcept C34688535 @default.
• W1988762859 hasConcept C552990157 @default.
• W1988762859 hasConcept C55493867 @default.
• W1988762859 hasConcept C67705224 @default.
• W1988762859 hasConcept C73573662 @default.
• W1988762859 hasConcept C76535049 @default.
• W1988762859 hasConcept C86803240 @default.
• W1988762859 hasConcept C88354546 @default.
• W1988762859 hasConcept C95444343 @default.
• W1988762859 hasConcept C98086919 @default.
• W1988762859 hasConceptScore W1988762859C104317684 @default.
• W1988762859 hasConceptScore W1988762859C104690221 @default.
• W1988762859 hasConceptScore W1988762859C131140672 @default.
• W1988762859 hasConceptScore W1988762859C151158763 @default.
• W1988762859 hasConceptScore W1988762859C153911025 @default.
• W1988762859 hasConceptScore W1988762859C156719811 @default.
• W1988762859 hasConceptScore W1988762859C188036394 @default.
• W1988762859 hasConceptScore W1988762859C2756471 @default.
• W1988762859 hasConceptScore W1988762859C31254050 @default.
• W1988762859 hasConceptScore W1988762859C34688535 @default.
• W1988762859 hasConceptScore W1988762859C552990157 @default.

• next