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- W1988768909 abstract "Infection by the Epstein–Barr virus (EBV) in immunocompetent individuals seems mainly confined to antigen-experienced memory B cells. However, a recent report shows that EBV+ post-transplant lymphoproliferative disease might arise not only from memory B cells but also from naı̈ve and germinal center (GC) B cells. Intriguingly, some of the EBV-positive B-cell clones seem to carry non-functional Ig-V-region genes as a result of deleterious somatic mutations acquired during the GC reaction. Given that such GC B cells are destined to die by apoptosis in the absence of EBV, these findings suggest that transformation by EBV might bypass negative selection of B cells within GCs." @default.
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- W1988768909 date "2003-06-01" @default.
- W1988768909 modified "2023-09-27" @default.
- W1988768909 title "Epstein–Barr virus and the B cell: a secret romance" @default.
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- W1988768909 doi "https://doi.org/10.1016/s0966-842x(03)00121-5" @default.
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