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- W1988769970 abstract "In this study, the ability of neurotrophin-5 (NT-4/5) to promote the proliferation of oligodendrocyte precursor (O-2A) cells has been examined. This has been accomplished by the addition of exogenous NT-4/5 to purified cultures of O-2A cells maintained in an undifferentiated state by the addition of the mitogens platelet derived growth factor (PDGF-AA) and basic fibroblast growth factor (bFGF). Counts of cells incorporating bromodeoxyuridine (BrdU) showed that the addition of NT-4/5 for 24 h increased O-2A cell proliferation by 1.8-fold above that seen in PDGF-AA and bFGF alone. These data demonstrate a previously unidentified role for the neurotrophin NT-4/5 in oligodendrocyte biology." @default.
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- W1988769970 date "2000-09-01" @default.
- W1988769970 modified "2023-10-15" @default.
- W1988769970 title "Neurotrophin-4/5 promotes proliferation of oligodendrocyte-type-2 astrocytes (O-2A)" @default.
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- W1988769970 doi "https://doi.org/10.1016/s0165-3806(00)00077-8" @default.
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