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• W1988796857 abstract "Selective metastasis is the formation of secondary tumors in an organ pattern that is peculiar. The reason for specific organ localization has not been established. I Clearly, prostatic carcinoma selectively spreads to bone. The predilection of prostatic cancer to metastasize to bone has been recognized since Thompson’ reported the very first case. In this review., the mechanisms of this metastasis to bone and the response within bone will be emphasized. Staging of carcinoma of the prostate is difficult because of a lack of absoluteness in clinical, surgical, and autopsy staging. Still, the concept is widespread that prostatic carcinoma begins as a small focus (Stage A) which, after some dormant period, enlarges to a palpable nodule (Stage B). After growing through the prostatic capsule (Stage C), the tumor spreads in an orderly manner through the pelvic lymph nodes (Stage :Dl), up the periaortic nodes, and then to bone. Whitmore, however, has pointed out that the natural history of prostatic carcinoma is unpredictable, which certainly confounds treatment regimens. Approximately 40 per cent of patients, hoveever, do present with Stage D disease with most of these having bone metastases. Metastases to bone occurs late in the natural history of each particular tumor, and patients with bone metastases are not expected to survive five years. Yet, 20 per cent of cases of Stage D carcinoma of the prostate do survive five yearse4 Patients with prostatic carcinoma die of their tumor,4.s but it takes them a long time to do so compared with other tumors. This might account for some of the increase in the number of bone metasases; that is patients with other carcinomas may die before clinical bone metastases become apparent. However, prostatic cancer not only metastasizes to and flourishes in bone, but also seems to exclude other sites, at least clinically." @default.
• W1988796857 created "2016-06-24" @default.
• W1988796857 creator A5091458648 @default.
• W1988796857 date "1983-04-01" @default.
• W1988796857 modified "2023-10-08" @default.
• W1988796857 title "Spread of prostatic cancer to bone" @default.
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• W1988796857 doi "https://doi.org/10.1016/0090-4295(83)90147-4" @default.
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