FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988820236> ?p ?o ?g. }

• W1988820236 endingPage "200" @default.
• W1988820236 startingPage "195" @default.
• W1988820236 abstract "Proopomelanocortin (POMC) is the precursor protein for a number of peptide hormones and neuropeptides, and the POMC gene is transcriptionally very active in the pars intermedia of the pituitary of the amphibian Xenopus laevis (Xenopus). We analysed the expression of this gene during Xenopus embryogenesis, in order to examine whether it can function as a (novel) neural marker. We investigated the spatio-temporal distribution of POMC mRNA, using a single-stranded probe that corresponds to the 3'untranslated region of Xenopus POMC gene B mRNA. Gene transcripts were first detected at stage 25 of development via RNase protection assays. In situ hybridization analysis performed at stage 46 showed clearly that these transcripts are localised in a region representing the future pars intermedia of the pituitary. Experiments using Xenopus explants indicate that the POMC gene can be used successfully as an indirect marker in studies on neural induction: in the absence of interactions with mesoderm, ectoderm fails to express the POMC gene, whereas POMC transcripts are readily detectable in conjugates of ectoderm and mesoderm. Artificial application of two different signals, which are likely to be relevant for neural differentiation (namely retinoic acid and the activation of protein kinase C via phorbol ester), was not effective in evoking POMC gene expression in cultured ectoderm explants. However, retinoic acid treatment of conjugates of Xenopus ectoderm and mesoderm successfully prevented POMC expression. We conclude that POMC gene expression can be used as an indirect marker for anterior neural differentiation in Xenopus." @default.
• W1988820236 created "2016-06-24" @default.
• W1988820236 creator A5007228442 @default.
• W1988820236 creator A5034641400 @default.
• W1988820236 creator A5043875163 @default.
• W1988820236 creator A5065762609 @default.
• W1988820236 creator A5090920078 @default.
• W1988820236 date "1993-03-01" @default.
• W1988820236 modified "2023-09-23" @default.
• W1988820236 title "Proopiomelanocortin gene expression as a neural marker during the embryonic development of Xenopus laevis" @default.
• W1988820236 cites W1563545224 @default.
• W1988820236 cites W1754503051 @default.
• W1988820236 cites W18052795 @default.
• W1988820236 cites W1904952683 @default.
• W1988820236 cites W1967426812 @default.
• W1988820236 cites W1973921994 @default.
• W1988820236 cites W1982579649 @default.
• W1988820236 cites W2011686502 @default.
• W1988820236 cites W2033678645 @default.
• W1988820236 cites W2053051844 @default.
• W1988820236 cites W2055043355 @default.
• W1988820236 cites W2064864270 @default.
• W1988820236 cites W2066097401 @default.
• W1988820236 cites W2068807517 @default.
• W1988820236 cites W2073320971 @default.
• W1988820236 cites W2074806929 @default.
• W1988820236 cites W2078119356 @default.
• W1988820236 cites W2083927989 @default.
• W1988820236 cites W2089018293 @default.
• W1988820236 cites W2090565260 @default.
• W1988820236 cites W2107332774 @default.
• W1988820236 cites W2113460448 @default.
• W1988820236 cites W2125619554 @default.
• W1988820236 cites W2127590525 @default.
• W1988820236 cites W2138563371 @default.
• W1988820236 cites W2141433061 @default.
• W1988820236 cites W2265750209 @default.
• W1988820236 cites W2286023804 @default.
• W1988820236 cites W2333851779 @default.
• W1988820236 cites W2404996591 @default.
• W1988820236 cites W2525735237 @default.
• W1988820236 doi "https://doi.org/10.1111/j.1432-0436.1993.tb00631.x" @default.
• W1988820236 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8482437" @default.
• W1988820236 hasPublicationYear "1993" @default.
• W1988820236 type Work @default.
• W1988820236 sameAs 1988820236 @default.
• W1988820236 citedByCount "5" @default.
• W1988820236 crossrefType "journal-article" @default.
• W1988820236 hasAuthorship W1988820236A5007228442 @default.
• W1988820236 hasAuthorship W1988820236A5034641400 @default.
• W1988820236 hasAuthorship W1988820236A5043875163 @default.
• W1988820236 hasAuthorship W1988820236A5065762609 @default.
• W1988820236 hasAuthorship W1988820236A5090920078 @default.
• W1988820236 hasConcept C104317684 @default.
• W1988820236 hasConcept C145103041 @default.
• W1988820236 hasConcept C150194340 @default.
• W1988820236 hasConcept C153911025 @default.
• W1988820236 hasConcept C196843134 @default.
• W1988820236 hasConcept C2779329299 @default.
• W1988820236 hasConcept C2779535977 @default.
• W1988820236 hasConcept C2780915607 @default.
• W1988820236 hasConcept C2781121885 @default.
• W1988820236 hasConcept C2781309135 @default.
• W1988820236 hasConcept C461258 @default.
• W1988820236 hasConcept C54355233 @default.
• W1988820236 hasConcept C86803240 @default.
• W1988820236 hasConcept C87073359 @default.
• W1988820236 hasConcept C95444343 @default.
• W1988820236 hasConceptScore W1988820236C104317684 @default.
• W1988820236 hasConceptScore W1988820236C145103041 @default.
• W1988820236 hasConceptScore W1988820236C150194340 @default.
• W1988820236 hasConceptScore W1988820236C153911025 @default.
• W1988820236 hasConceptScore W1988820236C196843134 @default.
• W1988820236 hasConceptScore W1988820236C2779329299 @default.
• W1988820236 hasConceptScore W1988820236C2779535977 @default.
• W1988820236 hasConceptScore W1988820236C2780915607 @default.
• W1988820236 hasConceptScore W1988820236C2781121885 @default.
• W1988820236 hasConceptScore W1988820236C2781309135 @default.
• W1988820236 hasConceptScore W1988820236C461258 @default.
• W1988820236 hasConceptScore W1988820236C54355233 @default.
• W1988820236 hasConceptScore W1988820236C86803240 @default.
• W1988820236 hasConceptScore W1988820236C87073359 @default.
• W1988820236 hasConceptScore W1988820236C95444343 @default.
• W1988820236 hasIssue "3" @default.
• W1988820236 hasLocation W19888202361 @default.
• W1988820236 hasLocation W19888202362 @default.
• W1988820236 hasOpenAccess W1988820236 @default.
• W1988820236 hasPrimaryLocation W19888202361 @default.
• W1988820236 hasRelatedWork W1983889061 @default.
• W1988820236 hasRelatedWork W1988820236 @default.
• W1988820236 hasRelatedWork W2009121916 @default.
• W1988820236 hasRelatedWork W2069639241 @default.
• W1988820236 hasRelatedWork W2100741356 @default.
• W1988820236 hasRelatedWork W2147073510 @default.
• W1988820236 hasRelatedWork W2147356914 @default.
• W1988820236 hasRelatedWork W2290825433 @default.
• W1988820236 hasRelatedWork W2298413697 @default.
• W1988820236 hasRelatedWork W2187505269 @default.

• next