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• W1988822020 abstract "Gold nanomaterials are immerging candidates in medical diagnosis and treatment. Among them, gold nanorods (Au NRs) are widely used for cancer treatment. Tiopronin as a novel thiol drug was used to stabilize Au NRs in this work. Doxorubicin (DOX), a chemotherapeutic drug which works by interacting with DNA to arrest the cell cycle and induce apoptosis, was linked to Au NRs through electrostatic reaction with tiopronin, to obtain Au-TIOP-DOX NRs. Au NRs are also regarded as hyperthermia agents for photothermal cancer treatment. This delivery system (Au-TIOP-DOX NRs) was designed for passively targeting tumor cells in cancer therapy. More importantly, the carboxyl groups of tiopronin can be modified with some biological molecules (DNA/RNA, peptides, or drugs) to make Au NRs as a novel drug-delivery system for cancer treatment." @default.
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• W1988822020 date "2013-06-23" @default.
• W1988822020 modified "2023-09-25" @default.
• W1988822020 title "Preparation and characterization of doxorubicin functionalized tiopronin-capped gold nanorods for cancer therapy" @default.
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• W1988822020 doi "https://doi.org/10.1007/s11434-013-5918-8" @default.
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