FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988822862> ?p ?o ?g. }

• W1988822862 endingPage "1015" @default.
• W1988822862 startingPage "1002" @default.
• W1988822862 abstract "Starting from experimental data proposing hematopoietic stem cells as candidates for cardiac repair, we postulated that human peripheral blood (PB) CD34+ cells mobilized by hematopoietic growth-factor (G-CSF) would contain cell subpopulations capable of regenerating post-ischemic myocardial damages.In a phase I clinical assay enrolling seven patients with acute myocardial infarct, we directly delivered to the injured myocardium autologous PB CD34+ cells previously mobilized by G-CSF, collected by leukapheresis and purified by immunoselection. In parallel, we looked for the eventual presence of cardiomyocytic and endothelial progenitor cells in leukapheresis products of these patients and controls, using flow cytometry, reverse transcription-quantitative (RTQ)-polymerase chain reaction (PCR), cell cultures and immunofluorescence analyzes.The whole clinical process was feasible and safe. All patients were alive at an average follow-up of 49 months (range 24-76 months). Improvement of heart function parameters became obvious from the third month following cell reinjection. Left ventricular ejection fraction values progressively and dramatically increased with time, associated with PetScan demonstration of myocardial structure regeneration and revascularization and New York Heart Association (NYHA) grade improvement. Furthermore, we identified PB CD34+ cell subpopulations expressing characteristics of both immature and mature endothelial and cardiomyocyte progenitor cells. In vitro CD34+ cell cultures on a specific medium induced development of adherent cells featuring morphologies, gene expression and immunocytochemistry characteristics of endothelial and cardiac muscle cells.Mobilized CD34+ cells contain stem cells committed along endothelial and cardiac differentiation pathways, which could play a key role in a proposed two-phase mechanism of myocardial regeneration after direct intracardiac delivery, probably being responsible for the long-term clinical benefit observed." @default.
• W1988822862 created "2016-06-24" @default.
• W1988822862 creator A5023008376 @default.
• W1988822862 creator A5024454510 @default.
• W1988822862 creator A5027973674 @default.
• W1988822862 creator A5045576636 @default.
• W1988822862 creator A5055317469 @default.
• W1988822862 creator A5072243285 @default.
• W1988822862 creator A5074019447 @default.
• W1988822862 creator A5076055685 @default.
• W1988822862 creator A5078629798 @default.
• W1988822862 creator A5079377314 @default.
• W1988822862 creator A5091885084 @default.
• W1988822862 date "2009-01-01" @default.
• W1988822862 modified "2023-10-13" @default.
• W1988822862 title "Long-term benefit of intracardiac delivery of autologous granulocyte–colony-stimulating factor-mobilized blood CD34+ cells containing cardiac progenitors on regional heart structure and function after myocardial infarct" @default.
• W1988822862 cites W1569560733 @default.
• W1988822862 cites W1631250427 @default.
• W1988822862 cites W1969986792 @default.
• W1988822862 cites W1977437881 @default.
• W1988822862 cites W1977872287 @default.
• W1988822862 cites W1979993133 @default.
• W1988822862 cites W1990967532 @default.
• W1988822862 cites W1999718698 @default.
• W1988822862 cites W2014771201 @default.
• W1988822862 cites W2021224652 @default.
• W1988822862 cites W2034885353 @default.
• W1988822862 cites W2035883624 @default.
• W1988822862 cites W2045909770 @default.
• W1988822862 cites W2049601214 @default.
• W1988822862 cites W2056834741 @default.
• W1988822862 cites W2065767970 @default.
• W1988822862 cites W2068380542 @default.
• W1988822862 cites W2087604634 @default.
• W1988822862 cites W2090041902 @default.
• W1988822862 cites W2110667326 @default.
• W1988822862 cites W2111486034 @default.
• W1988822862 cites W2123163588 @default.
• W1988822862 cites W2125155374 @default.
• W1988822862 cites W2125635123 @default.
• W1988822862 cites W2135860513 @default.
• W1988822862 cites W2138264396 @default.
• W1988822862 cites W2139234903 @default.
• W1988822862 cites W2147687016 @default.
• W1988822862 cites W2151722542 @default.
• W1988822862 cites W2155480378 @default.
• W1988822862 cites W2157742358 @default.
• W1988822862 cites W2158048826 @default.
• W1988822862 cites W2162106476 @default.
• W1988822862 cites W2164921610 @default.
• W1988822862 cites W2167595513 @default.
• W1988822862 cites W2328808046 @default.
• W1988822862 cites W4245465399 @default.
• W1988822862 doi "https://doi.org/10.3109/14653240903164963" @default.
• W1988822862 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19929464" @default.
• W1988822862 hasPublicationYear "2009" @default.
• W1988822862 type Work @default.
• W1988822862 sameAs 1988822862 @default.
• W1988822862 citedByCount "43" @default.
• W1988822862 countsByYear W19888228622012 @default.
• W1988822862 countsByYear W19888228622013 @default.
• W1988822862 countsByYear W19888228622014 @default.
• W1988822862 countsByYear W19888228622015 @default.
• W1988822862 countsByYear W19888228622016 @default.
• W1988822862 countsByYear W19888228622017 @default.
• W1988822862 countsByYear W19888228622018 @default.
• W1988822862 countsByYear W19888228622019 @default.
• W1988822862 countsByYear W19888228622020 @default.
• W1988822862 countsByYear W19888228622021 @default.
• W1988822862 countsByYear W19888228622022 @default.
• W1988822862 countsByYear W19888228622023 @default.
• W1988822862 crossrefType "journal-article" @default.
• W1988822862 hasAuthorship W1988822862A5023008376 @default.
• W1988822862 hasAuthorship W1988822862A5024454510 @default.
• W1988822862 hasAuthorship W1988822862A5027973674 @default.
• W1988822862 hasAuthorship W1988822862A5045576636 @default.
• W1988822862 hasAuthorship W1988822862A5055317469 @default.
• W1988822862 hasAuthorship W1988822862A5072243285 @default.
• W1988822862 hasAuthorship W1988822862A5074019447 @default.
• W1988822862 hasAuthorship W1988822862A5076055685 @default.
• W1988822862 hasAuthorship W1988822862A5078629798 @default.
• W1988822862 hasAuthorship W1988822862A5079377314 @default.
• W1988822862 hasAuthorship W1988822862A5091885084 @default.
• W1988822862 hasConcept C10205521 @default.
• W1988822862 hasConcept C109159458 @default.
• W1988822862 hasConcept C16685009 @default.
• W1988822862 hasConcept C201750760 @default.
• W1988822862 hasConcept C203014093 @default.
• W1988822862 hasConcept C2777371436 @default.
• W1988822862 hasConcept C28328180 @default.
• W1988822862 hasConcept C71924100 @default.
• W1988822862 hasConcept C86803240 @default.
• W1988822862 hasConcept C95444343 @default.
• W1988822862 hasConceptScore W1988822862C10205521 @default.
• W1988822862 hasConceptScore W1988822862C109159458 @default.
• W1988822862 hasConceptScore W1988822862C16685009 @default.
• W1988822862 hasConceptScore W1988822862C201750760 @default.
• W1988822862 hasConceptScore W1988822862C203014093 @default.

• next