Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988824105> ?p ?o ?g. }
- W1988824105 endingPage "1820" @default.
- W1988824105 startingPage "1812" @default.
- W1988824105 abstract "Vascular endothelial growth factor (VEGF) and αvβ3 integrin are key molecules that actively participate in tumor angiogenesis and metastasis. Some integrin-blocking molecules are currently under clinical trials for cancer and metastasis treatment. However, the mechanism of action of such inhibitors is not completely understood. We have previously demonstrated the anti-angiogenic and anti-metastatic properties of DisBa-01, a recombinant His-tag RGD-disintegrin from Bothrops alternatus snake venom in some experimental models. DisBa-01 blocks αvβ3 integrin binding to vitronectin and inhibits integrin-mediated downstream signaling cascades and cell migration. Here we add some new information on the mechanism of action of DisBa-01 in the tumor microenvironment. DisBa-01 supports the adhesion of fibroblasts and MDA-MB-231 breast cancer cells but it inhibits the adhesion of these cells to type I collagen under flow in high shear conditions, as a simulation of the blood stream. DisBa-01 does not affect the release of VEGF by fibroblasts or breast cancer cells but it strongly decreases the expression of VEGF mRNA and of its receptors, vascular endothelial growth factor receptors 1 and 2 (VEGFR1 and VEGFR2) in endothelial cells. DisBa-01 at nanomolar concentrations also modulates metalloprotease 2 (MMP-2) and 9 (MMP-9) activity, the latter being decreased in fibroblasts and increased in MDA-MB-231 cells. In conclusion, these results demonstrate that αvβ3 integrin inhibitors may induce distinct effects in the cells of the tumor microenvironment, resulting in blockade of angiogenesis by impairing of VEGF signaling and in inhibition of tumor cell motility." @default.
- W1988824105 created "2016-06-24" @default.
- W1988824105 creator A5002167500 @default.
- W1988824105 creator A5007923317 @default.
- W1988824105 creator A5008182211 @default.
- W1988824105 creator A5022445568 @default.
- W1988824105 creator A5023255264 @default.
- W1988824105 creator A5032294186 @default.
- W1988824105 creator A5064906036 @default.
- W1988824105 creator A5088553782 @default.
- W1988824105 date "2012-08-01" @default.
- W1988824105 modified "2023-09-26" @default.
- W1988824105 title "Blocking αvβ3 integrin by a recombinant RGD disintegrin impairs VEGF signaling in endothelial cells" @default.
- W1988824105 cites W147592962 @default.
- W1988824105 cites W1585254195 @default.
- W1988824105 cites W1904209158 @default.
- W1988824105 cites W1964749163 @default.
- W1988824105 cites W1967989242 @default.
- W1988824105 cites W1972102597 @default.
- W1988824105 cites W1977999028 @default.
- W1988824105 cites W1981037492 @default.
- W1988824105 cites W1983426119 @default.
- W1988824105 cites W1984824650 @default.
- W1988824105 cites W1988292203 @default.
- W1988824105 cites W1989305669 @default.
- W1988824105 cites W1989957765 @default.
- W1988824105 cites W1995470316 @default.
- W1988824105 cites W1995541867 @default.
- W1988824105 cites W2002606648 @default.
- W1988824105 cites W2004918005 @default.
- W1988824105 cites W2010418086 @default.
- W1988824105 cites W2011582582 @default.
- W1988824105 cites W2012063336 @default.
- W1988824105 cites W2012942237 @default.
- W1988824105 cites W2022233074 @default.
- W1988824105 cites W2028768078 @default.
- W1988824105 cites W2029979230 @default.
- W1988824105 cites W2031856001 @default.
- W1988824105 cites W2034291695 @default.
- W1988824105 cites W2039941561 @default.
- W1988824105 cites W2047161892 @default.
- W1988824105 cites W2052066052 @default.
- W1988824105 cites W2052818916 @default.
- W1988824105 cites W2053221827 @default.
- W1988824105 cites W2058239698 @default.
- W1988824105 cites W2064638030 @default.
- W1988824105 cites W2068046924 @default.
- W1988824105 cites W2072700424 @default.
- W1988824105 cites W2079323372 @default.
- W1988824105 cites W2081809673 @default.
- W1988824105 cites W2088056286 @default.
- W1988824105 cites W2089955644 @default.
- W1988824105 cites W2090625794 @default.
- W1988824105 cites W2091046599 @default.
- W1988824105 cites W2091774189 @default.
- W1988824105 cites W2098531320 @default.
- W1988824105 cites W2101994706 @default.
- W1988824105 cites W2103679891 @default.
- W1988824105 cites W2120941547 @default.
- W1988824105 cites W2123312554 @default.
- W1988824105 cites W2126890281 @default.
- W1988824105 cites W2131816567 @default.
- W1988824105 cites W2132801501 @default.
- W1988824105 cites W2134820714 @default.
- W1988824105 cites W2135627690 @default.
- W1988824105 cites W2136731274 @default.
- W1988824105 cites W2138429838 @default.
- W1988824105 cites W2139304914 @default.
- W1988824105 cites W2147000598 @default.
- W1988824105 cites W2151637779 @default.
- W1988824105 cites W2151993915 @default.
- W1988824105 cites W2166573361 @default.
- W1988824105 cites W2167107456 @default.
- W1988824105 doi "https://doi.org/10.1016/j.biochi.2012.04.020" @default.
- W1988824105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22561350" @default.
- W1988824105 hasPublicationYear "2012" @default.
- W1988824105 type Work @default.
- W1988824105 sameAs 1988824105 @default.
- W1988824105 citedByCount "35" @default.
- W1988824105 countsByYear W19888241052013 @default.
- W1988824105 countsByYear W19888241052014 @default.
- W1988824105 countsByYear W19888241052015 @default.
- W1988824105 countsByYear W19888241052016 @default.
- W1988824105 countsByYear W19888241052017 @default.
- W1988824105 countsByYear W19888241052018 @default.
- W1988824105 countsByYear W19888241052019 @default.
- W1988824105 countsByYear W19888241052020 @default.
- W1988824105 countsByYear W19888241052021 @default.
- W1988824105 countsByYear W19888241052022 @default.
- W1988824105 countsByYear W19888241052023 @default.
- W1988824105 crossrefType "journal-article" @default.
- W1988824105 hasAuthorship W1988824105A5002167500 @default.
- W1988824105 hasAuthorship W1988824105A5007923317 @default.
- W1988824105 hasAuthorship W1988824105A5008182211 @default.
- W1988824105 hasAuthorship W1988824105A5022445568 @default.
- W1988824105 hasAuthorship W1988824105A5023255264 @default.
- W1988824105 hasAuthorship W1988824105A5032294186 @default.
- W1988824105 hasAuthorship W1988824105A5064906036 @default.