FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988828500> ?p ?o ?g. }

• W1988828500 endingPage "220" @default.
• W1988828500 startingPage "213" @default.
• W1988828500 abstract "Intraalveolar fibrin formation is a hallmark of many acute and chronic lung inflammatory processes. We investigated the influence of fibrin polymerization on biochemical and biophysical properties of a calf lung surfactant extract (CLSE) used for therapy of neonatal distress syndrome. Thrombin-induced coagulation of human fibrinogen (range, 0.04 to 4 mg/ml) in the presence of CLSE (2 mg/ml phospholipids) resulted in progressive loss of surface tension-lowering properties and adsorption facilities of this surfactant preparation; the CLSE-inhibitory capacity of desAABB-fibrin surpassed that of fibrinogen by more than two orders of magnitude. In parallel with the loss of surface activity, association of the predominant surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) (14C-labeled, admixed to 2 mg/ml CLSE) with polymerizing desAABB-fibrin occurred. A volume of 0.3 mg/ml insoluble fibrin effected a ≈50% loss, and 0.6 mg/ml a > 90% loss, of DPPC from the aqueous phase. Dioleoylphosphatidylcholine, dipalmitoylphosphatidic acid, stearic acid, palmitic acid, and arachidonic acid, admixed to CLSE as labeled compounds, as well as total CLSE phospholipids were retained in polymerizing desAABB-fibrin with dose-effect curves superimposable to that of DPPC; no fibrin association was noted for 14C-glycerol-3-phosphate. Polymerizing desAA-fibrin, generated by incubation of CLSE-fibrinogen mixtures with arvin, captured DPPC and resulted in loss of surface properties at even lower concentrations, compared with desAABB-fibrin. In contrast, CLSE incubation with preformed desAABB- and desAA-fibrin polymers did not cause substantial phospholipid coupling with the clot material or loss of surface properties. Microtiter plate-immobilized fibrinogen and desAABB- and desAA-fibrinomonomers did not bind CLSE phospholipids enriched with 14C-DPPC. Soluble desAABB- and desAA-fibrinmonomers, generated in the presence of GLY-PRO-ARG-PRO, did not exhibit surfactant-inhibitory properties different from those of fibrinogen (minimum inhibitory concentrations > 12 mg/ml, as assessed on 2 mg/ml CLSE). We conclude that surfactant phospholipids and fatty acids strongly bind to polymerizing fibrin, but not to fibrinogen and fibrinmonomer, with concomitant loss of surface activity." @default.
• W1988828500 created "2016-06-24" @default.
• W1988828500 creator A5014295390 @default.
• W1988828500 creator A5016511599 @default.
• W1988828500 creator A5053873870 @default.
• W1988828500 creator A5055557989 @default.
• W1988828500 creator A5086416072 @default.
• W1988828500 date "1993-08-01" @default.
• W1988828500 modified "2023-10-10" @default.
• W1988828500 title "Lung Surfactant Phospholipids Associate with Polymerizing Fibrin: Loss of Surface Activity" @default.
• W1988828500 cites W102892713 @default.
• W1988828500 cites W1486474722 @default.
• W1988828500 cites W1510871961 @default.
• W1988828500 cites W1570392672 @default.
• W1988828500 cites W1814751417 @default.
• W1988828500 cites W1917099971 @default.
• W1988828500 cites W1963712708 @default.
• W1988828500 cites W1964288384 @default.
• W1988828500 cites W1968984911 @default.
• W1988828500 cites W1975969810 @default.
• W1988828500 cites W1976284504 @default.
• W1988828500 cites W1988996360 @default.
• W1988828500 cites W2007989315 @default.
• W1988828500 cites W2011339820 @default.
• W1988828500 cites W2013395566 @default.
• W1988828500 cites W2013998497 @default.
• W1988828500 cites W2018102891 @default.
• W1988828500 cites W2031353675 @default.
• W1988828500 cites W2039209582 @default.
• W1988828500 cites W2044401907 @default.
• W1988828500 cites W2048864483 @default.
• W1988828500 cites W2049057745 @default.
• W1988828500 cites W2058851118 @default.
• W1988828500 cites W2062232597 @default.
• W1988828500 cites W2068123131 @default.
• W1988828500 cites W2068294211 @default.
• W1988828500 cites W2077408379 @default.
• W1988828500 cites W2078364270 @default.
• W1988828500 cites W2082650314 @default.
• W1988828500 cites W2089468771 @default.
• W1988828500 cites W2096776805 @default.
• W1988828500 cites W2100837269 @default.
• W1988828500 cites W2102726541 @default.
• W1988828500 cites W2133310011 @default.
• W1988828500 cites W2135846300 @default.
• W1988828500 cites W2157997956 @default.
• W1988828500 cites W2169502257 @default.
• W1988828500 cites W2214742748 @default.
• W1988828500 cites W2227186091 @default.
• W1988828500 cites W2272372468 @default.
• W1988828500 cites W2283002613 @default.
• W1988828500 cites W2324312308 @default.
• W1988828500 cites W2394792557 @default.
• W1988828500 cites W2399753434 @default.
• W1988828500 cites W2413330692 @default.
• W1988828500 cites W2413341679 @default.
• W1988828500 cites W2429886851 @default.
• W1988828500 cites W2465162254 @default.
• W1988828500 cites W2583201994 @default.
• W1988828500 cites W34521598 @default.
• W1988828500 cites W612202566 @default.
• W1988828500 doi "https://doi.org/10.1165/ajrcmb/9.2.213" @default.
• W1988828500 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8338688" @default.
• W1988828500 hasPublicationYear "1993" @default.
• W1988828500 type Work @default.
• W1988828500 sameAs 1988828500 @default.
• W1988828500 citedByCount "74" @default.
• W1988828500 countsByYear W19888285002012 @default.
• W1988828500 countsByYear W19888285002013 @default.
• W1988828500 countsByYear W19888285002016 @default.
• W1988828500 countsByYear W19888285002018 @default.
• W1988828500 countsByYear W19888285002020 @default.
• W1988828500 countsByYear W19888285002021 @default.
• W1988828500 countsByYear W19888285002022 @default.
• W1988828500 crossrefType "journal-article" @default.
• W1988828500 hasAuthorship W1988828500A5014295390 @default.
• W1988828500 hasAuthorship W1988828500A5016511599 @default.
• W1988828500 hasAuthorship W1988828500A5053873870 @default.
• W1988828500 hasAuthorship W1988828500A5055557989 @default.
• W1988828500 hasAuthorship W1988828500A5086416072 @default.
• W1988828500 hasConcept C12554922 @default.
• W1988828500 hasConcept C178790620 @default.
• W1988828500 hasConcept C185592680 @default.
• W1988828500 hasConcept C203014093 @default.
• W1988828500 hasConcept C2776330855 @default.
• W1988828500 hasConcept C2777292125 @default.
• W1988828500 hasConcept C2778918659 @default.
• W1988828500 hasConcept C2779036427 @default.
• W1988828500 hasConcept C2781172473 @default.
• W1988828500 hasConcept C41625074 @default.
• W1988828500 hasConcept C43617362 @default.
• W1988828500 hasConcept C44228677 @default.
• W1988828500 hasConcept C521977710 @default.
• W1988828500 hasConcept C54173615 @default.
• W1988828500 hasConcept C55493867 @default.
• W1988828500 hasConcept C58226133 @default.
• W1988828500 hasConcept C86803240 @default.
• W1988828500 hasConcept C89560881 @default.

• next