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- W1988832019 abstract "Background: In a previous phase I clinical trial of dietary methionine (MET) restriction with cystemustine treatment for melanoma or glioma, we determined the optimal MET-free diet duration to be 1 day. On this basis, a phase II clinical trial was initiated to evaluate safety and efficacy of this combination. Patients and methods: Twenty-two patients (20 with metastatic melanoma and 2 with recurrent gloma) received a median of 4 cycles of the association of a 1-day MET-free diet with cystemustine (60 mg/m<sup>2</sup>) every two weeks. Results: This association was well tolerated (toxicity and nutritional status). Toxicity remained mainly hematological and consisted of WHO grade 3-4 thrombocytopenia, leucopenia and neutropenia in 36, 27 and 27% of patients respectively. The median disease-free survival was 1.8 months and the median survival was 4.6 months, with 2 long-duration stabilizations. The plasmatic MET depletion obtained was of 40±31%." @default.
- W1988832019 created "2016-06-24" @default.
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- W1988832019 date "2010-10-31" @default.
- W1988832019 modified "2023-09-25" @default.
- W1988832019 title "On the Persistence of Style Returns" @default.
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- W1988832019 doi "https://doi.org/10.3905/jpm.2010.37.1.015" @default.
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