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• W1988834200 endingPage "171" @default.
• W1988834200 startingPage "162" @default.
• W1988834200 abstract "The abuse of androgens may be related to their ability to produce positive, hedonic interoceptive effects. Conditioned Place Preference (CPP) has been used in many experiments to examine hedonic effects of drugs. This review is focused on studies from our laboratory that utilized CPP to examine potential positive hedonic effects of testosterone (T), and its androgenic metabolite dihydrotestosterone (DHT), and its metabolite 3α-androstanediol (3α-diol). We hypothesized that administration of a high concentration of 3α-diol would produce a CPP, pharmacological concentrations of plasma androgens, and alter androgen receptors (AR) and the function of GABAA/benzodiazepine receptor complexes (GBR). In our studies, we observed that systemic 3α-diol (1.0 mg/kg) prior to exposure to the non-preferred side of a CPP chamber significantly increased preference for the non-preferred side of the chamber compared to baseline preference and homecage controls. Furthermore, administration of T, DHT, or 3α-diol increased levels of these androgens, decreased ARs (decreased seminal vesicle weight and intrahypothalamic AR) and GBR function (decreased GABA-stimulated chloride influx in cortical synaptoneurosomes, and muscimol binding in the hippocampus compared to control groups). With systemic administration of 3α-diol that enhanced CPP, concentrations of 3α-diol were increased in the nucleus accumbens (NA). Central implants of T, DHT, or 3α-diol to the NA also produced a CPP compared to baseline preference and vehicle controls. These data indicate that systemic 3α-diol is more effective at enhancing CPP and increasing circulating 3α-diol levels than is T or DHT and that central administration of 3α-diol to the NA can condition a place preference. These findings indicate that 3α-diol produces positive hedonic effects and suggest that T’s variable effects on CPP may be due in part to T’s metabolism to 3α-diol." @default.
• W1988834200 created "2016-06-24" @default.
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• W1988834200 date "2001-11-01" @default.
• W1988834200 modified "2023-10-17" @default.
• W1988834200 title "The testosterone metabolite and neurosteroid 3α-androstanediol may mediate the effects of testosterone on conditioned place preference" @default.
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• W1988834200 doi "https://doi.org/10.1016/s0165-0173(01)00116-3" @default.
• W1988834200 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11744084" @default.
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