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- W1988839010 abstract "Reductions in the levels of the neuropeptide vasopressin (VP) and its receptors have been associated with schizophrenia. VP is also critical for appropriate social behaviors in humans as well as rodents. One of the prominent symptoms of schizophrenia is asociality and these symptoms may develop prodromally. A reduction in event-related potential (ERP) peak amplitudes is an endophenotype of schizophrenia. In this study, we use the Brattleboro (BRAT) rat to assess the role of VP deficiency in vocal communication during early development and on auditory ERPs during adulthood. BRAT rats had similar vocal communication to wild-type littermate controls during postnatal days 2 and 5 but the time between vocalizations was increased and the power of the vocalizations was reduced beginning at postnatal day 9. During adulthood, BRAT rats had deficits in auditory ERPs including reduced N40 amplitude and reduced low and high gamma intertrial coherence. These results suggest that the role of VP on vocal communication is an age-dependent process. Additionally, the deficits in ERPs indicate an impairment of auditory information processing related to the reduction in VP. Therefore, manipulation of the VP system could provide a novel mechanism for treatment for negative symptoms of schizophrenia." @default.
- W1988839010 created "2016-06-24" @default.
- W1988839010 creator A5029550098 @default.
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- W1988839010 creator A5089955873 @default.
- W1988839010 date "2013-10-01" @default.
- W1988839010 modified "2023-10-18" @default.
- W1988839010 title "Electroencephalographic and early communicative abnormalities in Brattleboro rats" @default.
- W1988839010 cites W1001130369 @default.
- W1988839010 cites W1498405988 @default.
- W1988839010 cites W1562350601 @default.
- W1988839010 cites W1956381018 @default.
- W1988839010 cites W1963957878 @default.
- W1988839010 cites W1966249266 @default.
- W1988839010 cites W1966458763 @default.
- W1988839010 cites W1966821800 @default.
- W1988839010 cites W1967821332 @default.
- W1988839010 cites W1969849910 @default.
- W1988839010 cites W1971984064 @default.
- W1988839010 cites W1974345292 @default.
- W1988839010 cites W1978061878 @default.
- W1988839010 cites W1984238104 @default.
- W1988839010 cites W1984540432 @default.
- W1988839010 cites W1987164603 @default.
- W1988839010 cites W1989736477 @default.
- W1988839010 cites W1991726755 @default.
- W1988839010 cites W1991779576 @default.
- W1988839010 cites W1994256475 @default.
- W1988839010 cites W1995558591 @default.
- W1988839010 cites W1999508859 @default.
- W1988839010 cites W2001896608 @default.
- W1988839010 cites W2004990019 @default.
- W1988839010 cites W2005143013 @default.
- W1988839010 cites W2007646590 @default.
- W1988839010 cites W2008122036 @default.
- W1988839010 cites W2012986211 @default.
- W1988839010 cites W2014966699 @default.
- W1988839010 cites W2015372331 @default.
- W1988839010 cites W2016850115 @default.
- W1988839010 cites W2017750602 @default.
- W1988839010 cites W2018242468 @default.
- W1988839010 cites W2027720046 @default.
- W1988839010 cites W2029832763 @default.
- W1988839010 cites W2030179847 @default.
- W1988839010 cites W2032670101 @default.
- W1988839010 cites W2032957338 @default.
- W1988839010 cites W2032985357 @default.
- W1988839010 cites W2033433729 @default.
- W1988839010 cites W2034108533 @default.
- W1988839010 cites W2034328588 @default.
- W1988839010 cites W2040249155 @default.
- W1988839010 cites W2041733608 @default.
- W1988839010 cites W2042076636 @default.
- W1988839010 cites W2044619557 @default.
- W1988839010 cites W2046048788 @default.
- W1988839010 cites W2048104747 @default.
- W1988839010 cites W2048921697 @default.
- W1988839010 cites W2055363829 @default.
- W1988839010 cites W2059866979 @default.
- W1988839010 cites W2060100040 @default.
- W1988839010 cites W2060517660 @default.
- W1988839010 cites W2062427475 @default.
- W1988839010 cites W2062502716 @default.
- W1988839010 cites W2067571602 @default.
- W1988839010 cites W2072741274 @default.
- W1988839010 cites W2073172123 @default.
- W1988839010 cites W2074174405 @default.
- W1988839010 cites W2074627454 @default.
- W1988839010 cites W2077415512 @default.
- W1988839010 cites W2077484805 @default.
- W1988839010 cites W2077863458 @default.
- W1988839010 cites W2078002432 @default.
- W1988839010 cites W2079258652 @default.
- W1988839010 cites W2084935484 @default.
- W1988839010 cites W2086572644 @default.
- W1988839010 cites W2086665513 @default.
- W1988839010 cites W2091782093 @default.
- W1988839010 cites W2095667216 @default.
- W1988839010 cites W2098076421 @default.
- W1988839010 cites W2108511845 @default.
- W1988839010 cites W2116944142 @default.
- W1988839010 cites W2127563942 @default.
- W1988839010 cites W2140041717 @default.
- W1988839010 cites W2141094317 @default.
- W1988839010 cites W2145602532 @default.
- W1988839010 cites W2149244679 @default.
- W1988839010 cites W2158765675 @default.
- W1988839010 cites W2159021356 @default.
- W1988839010 cites W2164713150 @default.
- W1988839010 cites W2164859750 @default.
- W1988839010 cites W2169944034 @default.
- W1988839010 cites W2784685795 @default.
- W1988839010 cites W4214953333 @default.
- W1988839010 doi "https://doi.org/10.1002/phy2.100" @default.
- W1988839010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3841036" @default.