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- W1988841780 abstract "The mechanical forces acting on SMC in the vascular wall are known to regulate processes such as vascular remodeling and contractile differentiation. However, investigations to elucidate the underlying mechanisms of mechanotransduction in smooth muscle have been hampered by technical limitations associated with mechanical studies on pressurized small arteries, due primarily to the small amount of available tissue. The murine portal vein is a relatively large vessel showing myogenic tone that in many respects recapitulates the properties of small resistance vessels. Studies on stretched portal veins to elucidate mechanisms of mechanotransduction in the vascular wall have shown that stretch-sensitive regulation of contractile differentiation is mediated via Rho-activation and actin polymerization, while stretch-induced growth is regulated by the MAPK pathway. In this review, we have summarized findings on mechanotransduction in the portal vein with focus on stretch-induced contractile differentiation and the role of calcium, actin polymerization and miRNAs in this response." @default.
- W1988841780 created "2016-06-24" @default.
- W1988841780 creator A5006983556 @default.
- W1988841780 creator A5017827825 @default.
- W1988841780 creator A5056632743 @default.
- W1988841780 date "2014-04-01" @default.
- W1988841780 modified "2023-10-13" @default.
- W1988841780 title "Stretch-Dependent Smooth Muscle Differentiation in the Portal Vein-Role of Actin Polymerization, Calcium Signaling, and microRNAs" @default.
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- W1988841780 doi "https://doi.org/10.1111/micc.12106" @default.
- W1988841780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24238368" @default.
- W1988841780 hasPublicationYear "2014" @default.
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