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• W1988846285 endingPage "3486" @default.
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• W1988846285 abstract "Pinpointing of phosphorylation sites by positive ion collision-induced dissociation (CID) in phosphopeptides containing consecutive Ser/Thr residues (Ser/Thr clusters) is frequently hampered by the lack of backbone cleavage between adjacent Ser/Thr or pSer/pThr sites. In this study, we demonstrate that in negative ion collision-induced dissociation phosphorylated and unmodified residues of Ser/Thr clusters exhibit a very selective behavior toward cleavage of their N-Calpha bonds. Ser/Thr clusters were defined as two and more consecutive serine or threonine residues in phosphopeptide sequences. Dissociation reactions at pSer are significantly more abundant than those of unmodified sites. Thr residues exhibit the same effect, but the cleavages occurring at pThr are generally less prominent than those at pSer. The correlation observed between the facility of the amine backbone bond dissociation of phosphopeptides and the presence of the phosphate group on the side chain residues of Ser and Thr is attributed to the different magnitudes of electron density on the Calpha atoms of the amino acid in phosphorylated and unmodified forms. The results of this study indicate that the intensity ratio of the fragments generated by N-Calpha bond cleavage within the phosphopeptide Ser/Thr clusters represents a reliable and general marker for pinpointing of phosphorylation sites. The presented data illustrate that negative ion electrospray CID is superior over the standard positive ion mode approach for the localization of protein phosphorylation inside Ser/Thr clusters." @default.
• W1988846285 created "2016-06-24" @default.
• W1988846285 creator A5004938208 @default.
• W1988846285 creator A5049415417 @default.
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• W1988846285 date "2007-03-28" @default.
• W1988846285 modified "2023-10-12" @default.
• W1988846285 title "Analysis of Protein Phosphorylation in the Regions of Consecutive Serine/Threonine Residues by Negative Ion Electrospray Collision-Induced Dissociation. Approach to Pinpointing of Phosphorylation Sites" @default.
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• W1988846285 doi "https://doi.org/10.1021/ac0623991" @default.
• W1988846285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17388569" @default.
• W1988846285 hasPublicationYear "2007" @default.
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