FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988848183> ?p ?o ?g. }

• W1988848183 endingPage "116" @default.
• W1988848183 startingPage "113" @default.
• W1988848183 abstract "Schizophrenia is a chronic disorder generally considered to encompass positive symptoms, negative symptoms and cognitive deficits. Increasing attention has been paid to the social cognitive deficits of the disorder as these dysfunctions are particularly handicapping, predictive of functional outcome and show poor treatment response. Phencyclidine (PCP) is a psychotomimetic drug used to model the different aspects of schizophrenia in experimental animal models. PCP-induced cognitive deficits and hyperlocomotion may be blocked by pretreatment with nitric oxide (NO) synthase inhibitors in rodents. The present study was carried out to evaluate the acute effects of PCP and NO synthase inhibition on social interaction in male Sprague-Dawley rats. The NO synthase inhibitor, L-NAME (10mg/kg) and PCP (2mg/kg) was injected subcutaneously to rats, which were then tested in pairs for social interactive behaviour. Twenty-four hours after the initial test a drug-free social interaction test was carried out to assess the rats' memory of the previous social interaction. The results showed that PCP reduced the time of social interaction on Day 1 compared to controls, and that pretreatment with the NO synthase inhibitor, L-NAME, attenuated this reduction towards control levels. Neither locomotor activity, nor frequency of social interactions were affected by the PCP treatment, suggesting that the PCP-induced effects observed were not due to drug-induced stereotypies. In combination with increasing clinical evidence for the involvement of NO in the pathophysiology of schizophrenia, the present results indicate that NO synthase inhibition may be a potentially new treatment strategy for alleviating social dysfunction in schizophrenia." @default.
• W1988848183 created "2016-06-24" @default.
• W1988848183 creator A5023910856 @default.
• W1988848183 creator A5067701153 @default.
• W1988848183 creator A5088376440 @default.
• W1988848183 creator A5089192575 @default.
• W1988848183 date "2009-06-01" @default.
• W1988848183 modified "2023-09-25" @default.
• W1988848183 title "The importance of nitric oxide in social dysfunction" @default.
• W1988848183 cites W1616286551 @default.
• W1988848183 cites W1914381346 @default.
• W1988848183 cites W1971655504 @default.
• W1988848183 cites W1980850343 @default.
• W1988848183 cites W1981772951 @default.
• W1988848183 cites W1982274699 @default.
• W1988848183 cites W1986487757 @default.
• W1988848183 cites W1997695932 @default.
• W1988848183 cites W2002574486 @default.
• W1988848183 cites W2003935114 @default.
• W1988848183 cites W2010383783 @default.
• W1988848183 cites W2013557366 @default.
• W1988848183 cites W2019298924 @default.
• W1988848183 cites W2022491522 @default.
• W1988848183 cites W2022495097 @default.
• W1988848183 cites W2027336096 @default.
• W1988848183 cites W2027588500 @default.
• W1988848183 cites W2030247720 @default.
• W1988848183 cites W2030339087 @default.
• W1988848183 cites W2032193303 @default.
• W1988848183 cites W2035815094 @default.
• W1988848183 cites W2040596817 @default.
• W1988848183 cites W2041731069 @default.
• W1988848183 cites W2049428499 @default.
• W1988848183 cites W2050431276 @default.
• W1988848183 cites W2052566586 @default.
• W1988848183 cites W2055100089 @default.
• W1988848183 cites W2058045718 @default.
• W1988848183 cites W2069050260 @default.
• W1988848183 cites W2086326767 @default.
• W1988848183 cites W2087828327 @default.
• W1988848183 cites W2100934182 @default.
• W1988848183 cites W2101882973 @default.
• W1988848183 cites W2101928318 @default.
• W1988848183 cites W2102303216 @default.
• W1988848183 cites W2133760600 @default.
• W1988848183 cites W2135470917 @default.
• W1988848183 cites W2138368199 @default.
• W1988848183 cites W2140156016 @default.
• W1988848183 doi "https://doi.org/10.1016/j.bbr.2009.01.002" @default.
• W1988848183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19166879" @default.
• W1988848183 hasPublicationYear "2009" @default.
• W1988848183 type Work @default.
• W1988848183 sameAs 1988848183 @default.
• W1988848183 citedByCount "19" @default.
• W1988848183 countsByYear W19888481832012 @default.
• W1988848183 countsByYear W19888481832013 @default.
• W1988848183 countsByYear W19888481832014 @default.
• W1988848183 countsByYear W19888481832015 @default.
• W1988848183 countsByYear W19888481832016 @default.
• W1988848183 countsByYear W19888481832017 @default.
• W1988848183 countsByYear W19888481832020 @default.
• W1988848183 countsByYear W19888481832021 @default.
• W1988848183 crossrefType "journal-article" @default.
• W1988848183 hasAuthorship W1988848183A5023910856 @default.
• W1988848183 hasAuthorship W1988848183A5067701153 @default.
• W1988848183 hasAuthorship W1988848183A5088376440 @default.
• W1988848183 hasAuthorship W1988848183A5089192575 @default.
• W1988848183 hasConcept C118552586 @default.
• W1988848183 hasConcept C126322002 @default.
• W1988848183 hasConcept C15744967 @default.
• W1988848183 hasConcept C169760540 @default.
• W1988848183 hasConcept C169900460 @default.
• W1988848183 hasConcept C170493617 @default.
• W1988848183 hasConcept C2776412080 @default.
• W1988848183 hasConcept C2777622882 @default.
• W1988848183 hasConcept C2778851735 @default.
• W1988848183 hasConcept C2781065190 @default.
• W1988848183 hasConcept C519581460 @default.
• W1988848183 hasConcept C67018056 @default.
• W1988848183 hasConcept C71924100 @default.
• W1988848183 hasConcept C98274493 @default.
• W1988848183 hasConceptScore W1988848183C118552586 @default.
• W1988848183 hasConceptScore W1988848183C126322002 @default.
• W1988848183 hasConceptScore W1988848183C15744967 @default.
• W1988848183 hasConceptScore W1988848183C169760540 @default.
• W1988848183 hasConceptScore W1988848183C169900460 @default.
• W1988848183 hasConceptScore W1988848183C170493617 @default.
• W1988848183 hasConceptScore W1988848183C2776412080 @default.
• W1988848183 hasConceptScore W1988848183C2777622882 @default.
• W1988848183 hasConceptScore W1988848183C2778851735 @default.
• W1988848183 hasConceptScore W1988848183C2781065190 @default.
• W1988848183 hasConceptScore W1988848183C519581460 @default.
• W1988848183 hasConceptScore W1988848183C67018056 @default.
• W1988848183 hasConceptScore W1988848183C71924100 @default.
• W1988848183 hasConceptScore W1988848183C98274493 @default.
• W1988848183 hasIssue "1" @default.
• W1988848183 hasLocation W19888481831 @default.
• W1988848183 hasLocation W19888481832 @default.

• next