Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988852892> ?p ?o ?g. }
- W1988852892 endingPage "751" @default.
- W1988852892 startingPage "742" @default.
- W1988852892 abstract "The general control nonderepressible 2 (GCN2) kinase is a nutrient-sensing pathway that responds to amino acids deficiency and induces a genetic program to effectively maintain cellular homeostasis. Here we established the conserved role of Caenorhabditis elegans GCN-2 under amino acid limitation as a translation initiation factor 2 (eIF2) kinase. Using a combination of genetic and molecular approaches, we showed that GCN-2 kinase activity plays a central role in survival under nutrient stress and mediates lifespan extension conferred by dietary restriction (DR) or inhibition of the major nutrient-sensing pathway, the target of rapamycin (TOR). We also demonstrated that the GCN-2 and TOR signaling pathways converge on the PHA-4/FoxA transcription factor and its downstream target genes to ensure survival of the whole organism under a multitude of stress conditions, such as nutrient scarcity or environmental stresses. This is one step forward in the understanding of evolutionary conserved mechanisms that confer longevity and healthspan." @default.
- W1988852892 created "2016-06-24" @default.
- W1988852892 creator A5014844316 @default.
- W1988852892 creator A5014915550 @default.
- W1988852892 creator A5022423933 @default.
- W1988852892 creator A5025255275 @default.
- W1988852892 creator A5035185524 @default.
- W1988852892 creator A5072421554 @default.
- W1988852892 date "2013-06-28" @default.
- W1988852892 modified "2023-10-01" @default.
- W1988852892 title "The general control nonderepressible‐2 kinase mediates stress response and longevity induced by target of rapamycin inactivation in<i><scp>C</scp>aenorhabditis elegans</i>" @default.
- W1988852892 cites W1533255176 @default.
- W1988852892 cites W1679586874 @default.
- W1988852892 cites W1908698496 @default.
- W1988852892 cites W1966901093 @default.
- W1988852892 cites W1967588638 @default.
- W1988852892 cites W1973856122 @default.
- W1988852892 cites W1980438612 @default.
- W1988852892 cites W1994305081 @default.
- W1988852892 cites W2002088854 @default.
- W1988852892 cites W2002636911 @default.
- W1988852892 cites W2002741326 @default.
- W1988852892 cites W2004129180 @default.
- W1988852892 cites W2016107719 @default.
- W1988852892 cites W2025894991 @default.
- W1988852892 cites W2027821655 @default.
- W1988852892 cites W2039196160 @default.
- W1988852892 cites W2043738446 @default.
- W1988852892 cites W2046913124 @default.
- W1988852892 cites W2048004251 @default.
- W1988852892 cites W2059916510 @default.
- W1988852892 cites W2064813406 @default.
- W1988852892 cites W2069993428 @default.
- W1988852892 cites W2070762373 @default.
- W1988852892 cites W2073701988 @default.
- W1988852892 cites W2077612844 @default.
- W1988852892 cites W2078903854 @default.
- W1988852892 cites W2086691574 @default.
- W1988852892 cites W2086812731 @default.
- W1988852892 cites W2087527859 @default.
- W1988852892 cites W2104052062 @default.
- W1988852892 cites W2104431515 @default.
- W1988852892 cites W2109535551 @default.
- W1988852892 cites W2111822899 @default.
- W1988852892 cites W2113516488 @default.
- W1988852892 cites W2123754932 @default.
- W1988852892 cites W2131632095 @default.
- W1988852892 cites W2134224359 @default.
- W1988852892 cites W2138138136 @default.
- W1988852892 cites W2145084130 @default.
- W1988852892 cites W2148581106 @default.
- W1988852892 cites W2158016476 @default.
- W1988852892 cites W2158616898 @default.
- W1988852892 cites W2160718564 @default.
- W1988852892 cites W2169696860 @default.
- W1988852892 doi "https://doi.org/10.1111/acel.12101" @default.
- W1988852892 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4225475" @default.
- W1988852892 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23692540" @default.
- W1988852892 hasPublicationYear "2013" @default.
- W1988852892 type Work @default.
- W1988852892 sameAs 1988852892 @default.
- W1988852892 citedByCount "51" @default.
- W1988852892 countsByYear W19888528922014 @default.
- W1988852892 countsByYear W19888528922015 @default.
- W1988852892 countsByYear W19888528922016 @default.
- W1988852892 countsByYear W19888528922017 @default.
- W1988852892 countsByYear W19888528922019 @default.
- W1988852892 countsByYear W19888528922020 @default.
- W1988852892 countsByYear W19888528922021 @default.
- W1988852892 countsByYear W19888528922022 @default.
- W1988852892 countsByYear W19888528922023 @default.
- W1988852892 crossrefType "journal-article" @default.
- W1988852892 hasAuthorship W1988852892A5014844316 @default.
- W1988852892 hasAuthorship W1988852892A5014915550 @default.
- W1988852892 hasAuthorship W1988852892A5022423933 @default.
- W1988852892 hasAuthorship W1988852892A5025255275 @default.
- W1988852892 hasAuthorship W1988852892A5035185524 @default.
- W1988852892 hasAuthorship W1988852892A5072421554 @default.
- W1988852892 hasBestOaLocation W19888528922 @default.
- W1988852892 hasConcept C104317684 @default.
- W1988852892 hasConcept C127716648 @default.
- W1988852892 hasConcept C184235292 @default.
- W1988852892 hasConcept C19843653 @default.
- W1988852892 hasConcept C207177822 @default.
- W1988852892 hasConcept C2776030549 @default.
- W1988852892 hasConcept C2776759703 @default.
- W1988852892 hasConcept C2778944004 @default.
- W1988852892 hasConcept C2909523446 @default.
- W1988852892 hasConcept C515207424 @default.
- W1988852892 hasConcept C54355233 @default.
- W1988852892 hasConcept C55493867 @default.
- W1988852892 hasConcept C62478195 @default.
- W1988852892 hasConcept C86339819 @default.
- W1988852892 hasConcept C86803240 @default.
- W1988852892 hasConcept C95444343 @default.
- W1988852892 hasConcept C97029542 @default.
- W1988852892 hasConceptScore W1988852892C104317684 @default.
- W1988852892 hasConceptScore W1988852892C127716648 @default.