FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988854865> ?p ?o ?g. }

• W1988854865 endingPage "e0119878" @default.
• W1988854865 startingPage "e0119878" @default.
• W1988854865 abstract "Molecular markers in bronchial fluids may contribute to the diagnosis of lung cancer. We previously observed a significant increase of C4d-containing complement degradation fragments in bronchoalveolar lavage (BAL) supernatants from lung cancer patients in a cohort of 50 cases and 22 controls (CUN cohort). The present study was designed to determine the diagnostic performance of these complement fragments (hereinafter jointly referred as C4d) in bronchial fluids. C4d levels were determined in BAL supernatants from two independent cohorts: the CU cohort (25 cases and 26 controls) and the HUVR cohort (60 cases and 98 controls). A series of spontaneous sputum samples from 68 patients with lung cancer and 10 controls was also used (LCCCIO cohort). Total protein content, complement C4, complement C5a, and CYFRA 21-1 were also measured in all cohorts. C4d levels were significantly increased in BAL samples from lung cancer patients. The area under the ROC curve was 0.82 (95%CI = 0.71-0.94) and 0.67 (95%CI = 0.58-0.76) for the CU and HUVR cohorts, respectively. In addition, unlike the other markers, C4d levels in BAL samples were highly consistent across the CUN, CU and HUVR cohorts. Interestingly, C4d test markedly increased the sensitivity of bronchoscopy in the two cohorts in which cytological data were available (CUN and HUVR cohorts). Finally, in the LCCCIO cohort, C4d levels were higher in sputum supernatants from patients with lung cancer (area under the ROC curve: 0.7; 95%CI = 0.56-0.83). In conclusion, C4d is consistently elevated in bronchial fluids from lung cancer patients and may be used to improve the diagnosis of the disease." @default.
• W1988854865 created "2016-06-24" @default.
• W1988854865 creator A5004034328 @default.
• W1988854865 creator A5011336970 @default.
• W1988854865 creator A5013585698 @default.
• W1988854865 creator A5024537192 @default.
• W1988854865 creator A5027132856 @default.
• W1988854865 creator A5028742920 @default.
• W1988854865 creator A5037597488 @default.
• W1988854865 creator A5051024704 @default.
• W1988854865 creator A5051485828 @default.
• W1988854865 creator A5052765751 @default.
• W1988854865 creator A5068141709 @default.
• W1988854865 creator A5073140995 @default.
• W1988854865 creator A5087506470 @default.
• W1988854865 creator A5089162981 @default.
• W1988854865 date "2015-03-23" @default.
• W1988854865 modified "2023-10-18" @default.
• W1988854865 title "Elevated Levels of the Complement Activation Product C4d in Bronchial Fluids for the Diagnosis of Lung Cancer" @default.
• W1988854865 cites W1487172145 @default.
• W1988854865 cites W149832289 @default.
• W1988854865 cites W1900099842 @default.
• W1988854865 cites W1968048579 @default.
• W1988854865 cites W1975429911 @default.
• W1988854865 cites W1979538859 @default.
• W1988854865 cites W1989207664 @default.
• W1988854865 cites W1993312546 @default.
• W1988854865 cites W1995870870 @default.
• W1988854865 cites W2022382160 @default.
• W1988854865 cites W2024857989 @default.
• W1988854865 cites W2039631325 @default.
• W1988854865 cites W2046965742 @default.
• W1988854865 cites W2050202446 @default.
• W1988854865 cites W2050973046 @default.
• W1988854865 cites W2057294521 @default.
• W1988854865 cites W2058113043 @default.
• W1988854865 cites W2078294783 @default.
• W1988854865 cites W2086737259 @default.
• W1988854865 cites W2087520779 @default.
• W1988854865 cites W2089421373 @default.
• W1988854865 cites W2096065464 @default.
• W1988854865 cites W2105293424 @default.
• W1988854865 cites W2112660237 @default.
• W1988854865 cites W2120723709 @default.
• W1988854865 cites W2126925889 @default.
• W1988854865 cites W2131499123 @default.
• W1988854865 cites W2132714469 @default.
• W1988854865 cites W2141817705 @default.
• W1988854865 cites W2144996768 @default.
• W1988854865 cites W2156057678 @default.
• W1988854865 cites W2157492758 @default.
• W1988854865 cites W2161817637 @default.
• W1988854865 cites W2167276220 @default.
• W1988854865 doi "https://doi.org/10.1371/journal.pone.0119878" @default.
• W1988854865 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4370816" @default.
• W1988854865 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25799154" @default.
• W1988854865 hasPublicationYear "2015" @default.
• W1988854865 type Work @default.
• W1988854865 sameAs 1988854865 @default.
• W1988854865 citedByCount "22" @default.
• W1988854865 countsByYear W19888548652015 @default.
• W1988854865 countsByYear W19888548652016 @default.
• W1988854865 countsByYear W19888548652017 @default.
• W1988854865 countsByYear W19888548652018 @default.
• W1988854865 countsByYear W19888548652019 @default.
• W1988854865 countsByYear W19888548652020 @default.
• W1988854865 countsByYear W19888548652021 @default.
• W1988854865 countsByYear W19888548652023 @default.
• W1988854865 crossrefType "journal-article" @default.
• W1988854865 hasAuthorship W1988854865A5004034328 @default.
• W1988854865 hasAuthorship W1988854865A5011336970 @default.
• W1988854865 hasAuthorship W1988854865A5013585698 @default.
• W1988854865 hasAuthorship W1988854865A5024537192 @default.
• W1988854865 hasAuthorship W1988854865A5027132856 @default.
• W1988854865 hasAuthorship W1988854865A5028742920 @default.
• W1988854865 hasAuthorship W1988854865A5037597488 @default.
• W1988854865 hasAuthorship W1988854865A5051024704 @default.
• W1988854865 hasAuthorship W1988854865A5051485828 @default.
• W1988854865 hasAuthorship W1988854865A5052765751 @default.
• W1988854865 hasAuthorship W1988854865A5068141709 @default.
• W1988854865 hasAuthorship W1988854865A5073140995 @default.
• W1988854865 hasAuthorship W1988854865A5087506470 @default.
• W1988854865 hasAuthorship W1988854865A5089162981 @default.
• W1988854865 hasBestOaLocation W19888548651 @default.
• W1988854865 hasConcept C126322002 @default.
• W1988854865 hasConcept C142724271 @default.
• W1988854865 hasConcept C203014093 @default.
• W1988854865 hasConcept C2776256026 @default.
• W1988854865 hasConcept C2776301714 @default.
• W1988854865 hasConcept C2777714996 @default.
• W1988854865 hasConcept C2777961210 @default.
• W1988854865 hasConcept C2781069245 @default.
• W1988854865 hasConcept C58471807 @default.
• W1988854865 hasConcept C71924100 @default.
• W1988854865 hasConcept C72563966 @default.
• W1988854865 hasConcept C76318530 @default.
• W1988854865 hasConcept C90924648 @default.
• W1988854865 hasConceptScore W1988854865C126322002 @default.

• next