FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988917926> ?p ?o ?g. }

• W1988917926 endingPage "431" @default.
• W1988917926 startingPage "418" @default.
• W1988917926 abstract "Background: Bisphosphonates are the treatment of choice for hypercalcaemia of malignancy (HCM) but there is no consensus regarding which drug or dose should be given. We designed a systematic review to investigate the efficacy of bisphosphonates in the treatment of HCM. Methods: We identified randomized controlled trials (RCTs) by searching electronic databases, scanning of reference lists, and consultation with experts and pharmaceutical companies. Foreign papers were translated. Inclusion criteria were RCTs, confirmed malignant disease and measurement of serum calcium (ionized or corrected for albumin) postrehydration. The primary outcome was number of patients achieving normocalcaemia. Secondary outcomes were time to normocalcaemia, time to relapse and toxicity. Results: Twenty-seven papers and two abstracts, using intravenous bisphosphonates, fulfilled the inclusion criteria. Data from 26 studies were used in analyses. Due to the heterogeneity of studies, meta-analysis could not be performed. Pamidronate was more effective than placebo, mithramycin, etidronate (7.5 mg/kg) and low-dose clodronate (600 mg), but equal to higher dose clodronate (1500 mg). Clodronate and etidronate were superior to placebo; incadronate was superior to elcatonin; gallium nitrate was superior to etidronate. No difference was seen between alendronate and clodronate. Three dose finding studies showed no difference between 30–90 mg of pamidronate, but one well designed study showed increasing efficacy with increasing dose. Studies using increasing doses of ibandronate (0.6–4 mg), alendronate (2.5–15 mg), and incadronate (2.5–10 mg), showed a dose response. Duration of administration of pamidronate did not affect efficacy (six studies). Conclusion: Bisphosphonates normalize calcium in 70% patients with minimal side effects. Aminobisphosphonates are most effective at maintaining normocalcaemia and should be given in high dose irrespective of baseline serum calcium." @default.
• W1988917926 created "2016-06-24" @default.
• W1988917926 creator A5044305592 @default.
• W1988917926 creator A5062636998 @default.
• W1988917926 creator A5080866538 @default.
• W1988917926 creator A5082774818 @default.
• W1988917926 creator A5089547051 @default.
• W1988917926 date "2004-07-01" @default.
• W1988917926 modified "2023-10-18" @default.
• W1988917926 title "Systematic review of bisphosphonates for hypercalcaemia of malignancy" @default.
• W1988917926 cites W1763483366 @default.
• W1988917926 cites W1883117309 @default.
• W1988917926 cites W1883130365 @default.
• W1988917926 cites W1932993947 @default.
• W1988917926 cites W1951349736 @default.
• W1988917926 cites W1966434911 @default.
• W1988917926 cites W1967548658 @default.
• W1988917926 cites W1971362943 @default.
• W1988917926 cites W1975805439 @default.
• W1988917926 cites W1977969585 @default.
• W1988917926 cites W1978169451 @default.
• W1988917926 cites W1980576844 @default.
• W1988917926 cites W1980657360 @default.
• W1988917926 cites W1984078397 @default.
• W1988917926 cites W1990049918 @default.
• W1988917926 cites W1996898338 @default.
• W1988917926 cites W1997364862 @default.
• W1988917926 cites W1998792681 @default.
• W1988917926 cites W2000582841 @default.
• W1988917926 cites W2001076963 @default.
• W1988917926 cites W2002986403 @default.
• W1988917926 cites W2004672175 @default.
• W1988917926 cites W2005231636 @default.
• W1988917926 cites W2009529772 @default.
• W1988917926 cites W2011666909 @default.
• W1988917926 cites W2013348835 @default.
• W1988917926 cites W2014098612 @default.
• W1988917926 cites W2016063742 @default.
• W1988917926 cites W2019392919 @default.
• W1988917926 cites W2021258692 @default.
• W1988917926 cites W2023853369 @default.
• W1988917926 cites W2024887507 @default.
• W1988917926 cites W2030300229 @default.
• W1988917926 cites W2033885211 @default.
• W1988917926 cites W2037019508 @default.
• W1988917926 cites W2040261060 @default.
• W1988917926 cites W2040303265 @default.
• W1988917926 cites W2049781559 @default.
• W1988917926 cites W2052544640 @default.
• W1988917926 cites W2052855337 @default.
• W1988917926 cites W2054887634 @default.
• W1988917926 cites W2057806510 @default.
• W1988917926 cites W2064935416 @default.
• W1988917926 cites W2068513137 @default.
• W1988917926 cites W2073998611 @default.
• W1988917926 cites W2077784259 @default.
• W1988917926 cites W2078468996 @default.
• W1988917926 cites W2084308139 @default.
• W1988917926 cites W2086591058 @default.
• W1988917926 cites W2088353545 @default.
• W1988917926 cites W2092562224 @default.
• W1988917926 cites W2092637573 @default.
• W1988917926 cites W2093164779 @default.
• W1988917926 cites W2094387987 @default.
• W1988917926 cites W2103245862 @default.
• W1988917926 cites W2112899211 @default.
• W1988917926 cites W2123070202 @default.
• W1988917926 cites W2145632791 @default.
• W1988917926 cites W2146306121 @default.
• W1988917926 cites W2180615502 @default.
• W1988917926 cites W2253228560 @default.
• W1988917926 cites W2272993042 @default.
• W1988917926 cites W2783103906 @default.
• W1988917926 cites W4243058305 @default.
• W1988917926 doi "https://doi.org/10.1191/0269216304pm914ra" @default.
• W1988917926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15332420" @default.
• W1988917926 hasPublicationYear "2004" @default.
• W1988917926 type Work @default.
• W1988917926 sameAs 1988917926 @default.
• W1988917926 citedByCount "56" @default.
• W1988917926 countsByYear W19889179262012 @default.
• W1988917926 countsByYear W19889179262013 @default.
• W1988917926 countsByYear W19889179262014 @default.
• W1988917926 countsByYear W19889179262016 @default.
• W1988917926 countsByYear W19889179262017 @default.
• W1988917926 countsByYear W19889179262018 @default.
• W1988917926 countsByYear W19889179262019 @default.
• W1988917926 countsByYear W19889179262021 @default.
• W1988917926 countsByYear W19889179262022 @default.
• W1988917926 countsByYear W19889179262023 @default.
• W1988917926 crossrefType "journal-article" @default.
• W1988917926 hasAuthorship W1988917926A5044305592 @default.
• W1988917926 hasAuthorship W1988917926A5062636998 @default.
• W1988917926 hasAuthorship W1988917926A5080866538 @default.
• W1988917926 hasAuthorship W1988917926A5082774818 @default.
• W1988917926 hasAuthorship W1988917926A5089547051 @default.
• W1988917926 hasConcept C126322002 @default.
• W1988917926 hasConcept C126894567 @default.

• next