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• W1988926013 abstract "PURPOSE: To compare the effects of mechanical versus alcohol-assisted epithelial debridement on corneal cellular elements after photorefractive keratectomy (PRK) using confocal microscopy. METHODS: This randomized, clinical trial included 66 eyes from 33 patients with spherical equivalent refraction <−4.00 diopters (D). Mechanical versus alcohol-assisted epithelial debridement was performed during PRK. The right eye of each patient was randomly assigned to one group (mechanical group or alcohol-assisted group) and the fellow eye to the alternate group. Confocal examination was performed preoperatively and at 3 and 6 months postoperatively. Main outcome measures were keratocyte density and maximum anterior stromal light reflectivity. RESULTS: Mean epithelial healing time was 3.2±0.4 and 3.0±0.3 days in the mechanical and alcohol-assisted groups, respectively ( P =.001). Anterior retroablation stromal keratocyte density was 704.3±119.9 cells/mm 2 and 734.3±103.7 cells/mm 2 at 3 months ( P =.05) and 643.8±134.4 cells/mm 2 and 696.7±129.6 cells/mm 2 at 6 months ( P =.02) in the mechanical and alcohol-assisted groups, respectively. No significant difference was noted in midstromal and posterior keratocyte density between the two groups. Maximum reflectivity was 61.56±12.64 international units (IU) and 56.93±7.86 IU in the mechanical and alcohol-assisted groups, respectively, 3 months after surgery ( P =.018). Corresponding values were 49.46±4.97 IU and 48.98±4.60 IU, respectively, 6 months after surgery ( P =.628). CONCLUSIONS: Due to more adverse effects of mechanical epithelial debridement on anterior keratocyte density and anterior stromal reflectivity, alcohol-assisted epithelial debridement is recommended as the procedure of choice for epithelial removal during PRK in patients with mild myopia." @default.
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• W1988926013 date "2011-12-01" @default.
• W1988926013 modified "2023-09-26" @default.
• W1988926013 title "Mechanical Versus Alcohol-assisted Epithelial Debridement During Photorefractive Keratectomy: A Confocal Microscopic Clinical Trial" @default.
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• W1988926013 doi "https://doi.org/10.3928/1081597x-20110823-02" @default.
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