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- W1988933337 abstract "Dogs were anaesthetized with pentobarbital and artificially ventilated, with gallamine as a relaxant. The effects of clonidine (Catapres®, 0.5–1.0 μg/kg) were observed on blood pressure, heart rate and on the reflex bradycardia elicited by i.v. injections of angiotensin, 0.0125–0.2 μg/kg or noradrenaline, 0.1–1.0 μg/kg. After blockade of cardiac sympathetic activity with the β-receptor antagonist KÖ 592, 5.0–7.5 mgg/kg, i.v. or of general sympathetic activity with guanethidine, 10 mg/kg, s.c., clonidine (Catapres®) injected into the cisterna cerebellomedullaris (i.ci.) significantly increased reflex bradycardia. This effect was not produced by i.v. clonidine or by i.ci. injection of the related imidazoline drug, naphazoline, 1 μg/kg. It is concluded that clonidine acts in the central nervous system to enhance vagally mediated reflex bradycardia." @default.
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- W1988933337 date "1972-08-01" @default.
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- W1988933337 title "Evidence for a central activation of a vagal cardiodepressor reflex by clonidine" @default.
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- W1988933337 doi "https://doi.org/10.1016/0014-2999(72)90010-6" @default.
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