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- W1988935360 abstract "In the present study, homovanillic acid in plasma (pHVA) and benzodiazepine receptors (3H-PK11195 binding) in neutrophil membranes were determined in blood ontained from cocaine-dependent (DSM-III-R) adult male inpatients at baseline (within 72 hr of last cocaine use) and after 3 weeks of cocaine abstinence, and normal controls. The mean (± SEM) pHVA at baseline (10.3 ng/ml ± 1.1) was similar to normals and did not change after 3 weeks of cocaine abstinence. Similarly, the binding indices of benzodiazepine receptors in cocaine-dependent subjects as a group were not significantly different than in normal controls. In 10 cocaine-dependent subjects, however, where both blood samples were available, the number of 3H-PK11195 binding sites was significantly (p < 0.05) decreased after 3 weeks of cocaine abstinence (mean ± sem: Bmax = 6371 ± 657 fmol/mg protein) compared with baseline (Bmax = 7553 ± 925 fmol/mg protein), although there were no differences in the binding affinity (mean ± sem: KD = 8.6 ± 1.2 nmol/L after 3 weeks of abstinence compared with 8.1 ± 1.0 nmol/L at baseline). These preliminary results suggests that peripheral benzodiazepine receptors may play an important role in the pathophysiology of cocaine withdrawal in cocaine-dependent human subjects." @default.
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- W1988935360 date "1994-07-01" @default.
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- W1988935360 title "Peripheral benzodiazepine receptors are decreased during cocaine withdrawal in humans" @default.
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- W1988935360 doi "https://doi.org/10.1016/0006-3223(94)90061-2" @default.
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