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- W1988949059 endingPage "193" @default.
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- W1988949059 abstract "Oxidase and oxygenase enzymes allow the use of relatively unreactive O2 in biochemical reactions. Many of the mechanistic strategies used in nature for this key reaction are represented within the 2-histidine-1-carboxylate facial triad family of non-heme Fe(II)-containing enzymes. The open face of the metal coordination sphere opposite the three endogenous ligands participates directly in the reaction chemistry. Here, data from several studies are presented showing that reductive O2 activation within this family is initiated by substrate (and in some cases cosubstrate or cofactor) binding, which then allows coordination of O2 to the metal. From this starting point, the O2 activation process and the reactions with substrates diverge broadly. The reactive species formed in these reactions have been proposed to encompass four oxidation states of iron and all forms of reduced O2 as well as several of the reactive oxygen species that derive from O-O bond cleavage." @default.
- W1988949059 created "2016-06-24" @default.
- W1988949059 creator A5019917073 @default.
- W1988949059 creator A5025513114 @default.
- W1988949059 date "2008-02-15" @default.
- W1988949059 modified "2023-10-10" @default.
- W1988949059 title "Versatility of biological non-heme Fe(II) centers in oxygen activation reactions" @default.
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- W1988949059 doi "https://doi.org/10.1038/nchembio.71" @default.
- W1988949059 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2720164" @default.
- W1988949059 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18277980" @default.
- W1988949059 hasPublicationYear "2008" @default.
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