FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988961198> ?p ?o ?g. }

• W1988961198 endingPage "3560" @default.
• W1988961198 startingPage "3547" @default.
• W1988961198 abstract "Tissue inhibitor of metalloproteinases-1 (TIMP-1) inhibits matrix metalloproteinases (MMPs) by binding at a 1:1 stoichiometry. Here we have shown the involvement of N-glycosylation in the MMP inhibitory ability of TIMP-1. TIMP-1, purified from HEK 293 cells overexpressing TIMP-1 (293 TIMP-1), showed less binding and inhibitory abilities to MMPs than TIMP-1 purified from fibroblasts or SF9 insect cells infected with TIMP-1 baculovirus. Following deglycosylation of TIMP-1, all forms of TIMP-1 showed similar levels of MMP binding and inhibition, suggesting that glycosylation is involved in the regulation of these TIMP-1 activities. Analysis of the N-glycan structures showed that SF9 TIMP-1 has the simplest N-glycan structures, followed by fibroblast TIMP-1 and 293 TIMP-1, in order of increasing complexity in their N-glycan structures. Further analyses showed that cleavage of outer arm fucose residues from the N-glycans of 293 TIMP-1 or knockdown of both FUT4 and FUT7 (which encode for fucosyltransferases that add outer arm fucose residues to N-glycans) enhanced the MMP-binding and catalytic abilities of 293 TIMP-1, bringing them up to the levels of the other TIMP-1. These results demonstrate that the ability of TIMP-1 to inhibit MMPs is at least in part regulated by outer arm fucosylation of its N-glycans." @default.
• W1988961198 created "2016-06-24" @default.
• W1988961198 creator A5013949668 @default.
• W1988961198 creator A5019907938 @default.
• W1988961198 creator A5038213140 @default.
• W1988961198 creator A5054269109 @default.
• W1988961198 creator A5057017443 @default.
• W1988961198 creator A5065092823 @default.
• W1988961198 creator A5072610663 @default.
• W1988961198 creator A5082473050 @default.
• W1988961198 creator A5082764933 @default.
• W1988961198 creator A5086928484 @default.
• W1988961198 creator A5091562783 @default.
• W1988961198 date "2013-07-01" @default.
• W1988961198 modified "2023-10-13" @default.
• W1988961198 title "The Presence of Outer Arm Fucose Residues on the <i>N</i>-Glycans of Tissue Inhibitor of Metalloproteinases-1 Reduces Its Activity" @default.
• W1988961198 cites W1491678226 @default.
• W1988961198 cites W1546653475 @default.
• W1988961198 cites W1720344590 @default.
• W1988961198 cites W1928161708 @default.
• W1988961198 cites W1965876379 @default.
• W1988961198 cites W1966025897 @default.
• W1988961198 cites W1971343950 @default.
• W1988961198 cites W1971723254 @default.
• W1988961198 cites W1973491666 @default.
• W1988961198 cites W1974537941 @default.
• W1988961198 cites W1979185609 @default.
• W1988961198 cites W1983979204 @default.
• W1988961198 cites W1984716997 @default.
• W1988961198 cites W1987565277 @default.
• W1988961198 cites W1997315604 @default.
• W1988961198 cites W1997389932 @default.
• W1988961198 cites W1999629817 @default.
• W1988961198 cites W2000212022 @default.
• W1988961198 cites W2000508583 @default.
• W1988961198 cites W2008545486 @default.
• W1988961198 cites W2012348648 @default.
• W1988961198 cites W2028231353 @default.
• W1988961198 cites W2034959888 @default.
• W1988961198 cites W2041568749 @default.
• W1988961198 cites W2043678021 @default.
• W1988961198 cites W2046280437 @default.
• W1988961198 cites W2050848743 @default.
• W1988961198 cites W2052528675 @default.
• W1988961198 cites W2056901325 @default.
• W1988961198 cites W2058188797 @default.
• W1988961198 cites W2059983738 @default.
• W1988961198 cites W2066457573 @default.
• W1988961198 cites W2067376871 @default.
• W1988961198 cites W2074589683 @default.
• W1988961198 cites W2082838889 @default.
• W1988961198 cites W2083260383 @default.
• W1988961198 cites W2087735019 @default.
• W1988961198 cites W2088405860 @default.
• W1988961198 cites W2088790264 @default.
• W1988961198 cites W2091988137 @default.
• W1988961198 cites W2097579313 @default.
• W1988961198 cites W2100837269 @default.
• W1988961198 cites W2105172384 @default.
• W1988961198 cites W2107017911 @default.
• W1988961198 cites W2123869107 @default.
• W1988961198 cites W2124268404 @default.
• W1988961198 cites W2130479394 @default.
• W1988961198 cites W2132240438 @default.
• W1988961198 cites W2143743796 @default.
• W1988961198 cites W2152487395 @default.
• W1988961198 cites W28646162 @default.
• W1988961198 cites W2949867270 @default.
• W1988961198 doi "https://doi.org/10.1021/pr400276r" @default.
• W1988961198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23815085" @default.
• W1988961198 hasPublicationYear "2013" @default.
• W1988961198 type Work @default.
• W1988961198 sameAs 1988961198 @default.
• W1988961198 citedByCount "17" @default.
• W1988961198 countsByYear W19889611982014 @default.
• W1988961198 countsByYear W19889611982015 @default.
• W1988961198 countsByYear W19889611982016 @default.
• W1988961198 countsByYear W19889611982018 @default.
• W1988961198 countsByYear W19889611982020 @default.
• W1988961198 countsByYear W19889611982021 @default.
• W1988961198 countsByYear W19889611982022 @default.
• W1988961198 countsByYear W19889611982023 @default.
• W1988961198 crossrefType "journal-article" @default.
• W1988961198 hasAuthorship W1988961198A5013949668 @default.
• W1988961198 hasAuthorship W1988961198A5019907938 @default.
• W1988961198 hasAuthorship W1988961198A5038213140 @default.
• W1988961198 hasAuthorship W1988961198A5054269109 @default.
• W1988961198 hasAuthorship W1988961198A5057017443 @default.
• W1988961198 hasAuthorship W1988961198A5065092823 @default.
• W1988961198 hasAuthorship W1988961198A5072610663 @default.
• W1988961198 hasAuthorship W1988961198A5082473050 @default.
• W1988961198 hasAuthorship W1988961198A5082764933 @default.
• W1988961198 hasAuthorship W1988961198A5086928484 @default.
• W1988961198 hasAuthorship W1988961198A5091562783 @default.
• W1988961198 hasConcept C103878061 @default.
• W1988961198 hasConcept C104317684 @default.
• W1988961198 hasConcept C108625454 @default.
• W1988961198 hasConcept C109523444 @default.

• next