Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988963232> ?p ?o ?g. }
- W1988963232 endingPage "2235" @default.
- W1988963232 startingPage "2226" @default.
- W1988963232 abstract "Obesity and metabolic syndrome are recognized risk factors for development of hepatocellular carcinoma (HCC) in patients with chronic hepatitis C (CHC). Dysregulation of adipokines, particularly the decreased secretion of adiponectin, appears to play a key role. To investigate the association between adiponectin and hepatocarcinogenesis, we conducted a large-scale retrospective cohort study. We enrolled 325 patients with CHC (146 men, 179 women; mean age 58.0 ± 10.3 years) whose serum samples were collected between January 1994 and December 2002. Subjects were divided into two groups according to their serum adiponectin levels. We evaluated the association between adiponectin level and the risk of subsequent HCC development using univariate and multivariate Cox proportional hazard regression. Because average serum adiponectin level was higher in females than males, each gender was analyzed separately. Patients with CHC had significantly higher adiponectin levels than healthy controls. During the follow-up period (mean: 9.0 years), HCC developed in 122 subjects. Unexpectedly, subjects with higher serum adiponectin levels had a higher incidence of HCC (males: p = 0.032; females: p = 0.01; log-rank test). Multivariate analysis revealed that a high serum adiponectin level was independently associated with HCC development (hazard ratio [HR] = 2.07; p = 0.031 in females and HR = 1.82; p = 0.05 in males). Isoform analysis revealed that middle- and low-molecular-weight isoforms contributed to the risk of HCC. In conclusion, Patients who had CHC with high serum adiponectin levels had a higher risk of liver cancer development. Adiponectin may thus be tumorigenic or indicate a liver disease state independently of other clinical parameters." @default.
- W1988963232 created "2016-06-24" @default.
- W1988963232 creator A5009751770 @default.
- W1988963232 creator A5009985299 @default.
- W1988963232 creator A5010116082 @default.
- W1988963232 creator A5012091678 @default.
- W1988963232 creator A5019510139 @default.
- W1988963232 creator A5023823880 @default.
- W1988963232 creator A5024011175 @default.
- W1988963232 creator A5034244372 @default.
- W1988963232 creator A5037009918 @default.
- W1988963232 creator A5046522736 @default.
- W1988963232 creator A5048851902 @default.
- W1988963232 creator A5053123676 @default.
- W1988963232 creator A5059201555 @default.
- W1988963232 creator A5065616638 @default.
- W1988963232 creator A5073692464 @default.
- W1988963232 date "2011-03-29" @default.
- W1988963232 modified "2023-10-11" @default.
- W1988963232 title "Serum level of adiponectin and the risk of liver cancer development in chronic hepatitis C patients" @default.
- W1988963232 cites W1965627493 @default.
- W1988963232 cites W1966357284 @default.
- W1988963232 cites W1981278284 @default.
- W1988963232 cites W1987963517 @default.
- W1988963232 cites W1994442324 @default.
- W1988963232 cites W1995000970 @default.
- W1988963232 cites W1996788067 @default.
- W1988963232 cites W1997048688 @default.
- W1988963232 cites W1997254448 @default.
- W1988963232 cites W1997978122 @default.
- W1988963232 cites W2004791698 @default.
- W1988963232 cites W2004973705 @default.
- W1988963232 cites W2012126216 @default.
- W1988963232 cites W2017149727 @default.
- W1988963232 cites W2025383646 @default.
- W1988963232 cites W2025618430 @default.
- W1988963232 cites W2027524383 @default.
- W1988963232 cites W2027961129 @default.
- W1988963232 cites W2030316166 @default.
- W1988963232 cites W2032789828 @default.
- W1988963232 cites W2035971119 @default.
- W1988963232 cites W2039845199 @default.
- W1988963232 cites W2044344375 @default.
- W1988963232 cites W2055417401 @default.
- W1988963232 cites W2071934739 @default.
- W1988963232 cites W2076310317 @default.
- W1988963232 cites W2088652574 @default.
- W1988963232 cites W2088876995 @default.
- W1988963232 cites W2095726149 @default.
- W1988963232 cites W2097196651 @default.
- W1988963232 cites W2103637700 @default.
- W1988963232 cites W2105617463 @default.
- W1988963232 cites W2107185209 @default.
- W1988963232 cites W2108931588 @default.
- W1988963232 cites W2112254863 @default.
- W1988963232 cites W2112377527 @default.
- W1988963232 cites W2118358710 @default.
- W1988963232 cites W2121002655 @default.
- W1988963232 cites W2125336233 @default.
- W1988963232 cites W2128485668 @default.
- W1988963232 cites W2134293572 @default.
- W1988963232 cites W2134524309 @default.
- W1988963232 cites W2137052325 @default.
- W1988963232 cites W2152746369 @default.
- W1988963232 cites W2167681464 @default.
- W1988963232 cites W2171354548 @default.
- W1988963232 cites W4246321297 @default.
- W1988963232 doi "https://doi.org/10.1002/ijc.25861" @default.
- W1988963232 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21170963" @default.
- W1988963232 hasPublicationYear "2011" @default.
- W1988963232 type Work @default.
- W1988963232 sameAs 1988963232 @default.
- W1988963232 citedByCount "69" @default.
- W1988963232 countsByYear W19889632322012 @default.
- W1988963232 countsByYear W19889632322013 @default.
- W1988963232 countsByYear W19889632322014 @default.
- W1988963232 countsByYear W19889632322015 @default.
- W1988963232 countsByYear W19889632322016 @default.
- W1988963232 countsByYear W19889632322017 @default.
- W1988963232 countsByYear W19889632322018 @default.
- W1988963232 countsByYear W19889632322019 @default.
- W1988963232 countsByYear W19889632322020 @default.
- W1988963232 countsByYear W19889632322021 @default.
- W1988963232 countsByYear W19889632322022 @default.
- W1988963232 countsByYear W19889632322023 @default.
- W1988963232 crossrefType "journal-article" @default.
- W1988963232 hasAuthorship W1988963232A5009751770 @default.
- W1988963232 hasAuthorship W1988963232A5009985299 @default.
- W1988963232 hasAuthorship W1988963232A5010116082 @default.
- W1988963232 hasAuthorship W1988963232A5012091678 @default.
- W1988963232 hasAuthorship W1988963232A5019510139 @default.
- W1988963232 hasAuthorship W1988963232A5023823880 @default.
- W1988963232 hasAuthorship W1988963232A5024011175 @default.
- W1988963232 hasAuthorship W1988963232A5034244372 @default.
- W1988963232 hasAuthorship W1988963232A5037009918 @default.
- W1988963232 hasAuthorship W1988963232A5046522736 @default.
- W1988963232 hasAuthorship W1988963232A5048851902 @default.
- W1988963232 hasAuthorship W1988963232A5053123676 @default.