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- W1988978696 abstract "Purpose: To investigate if nipradilol has an anti-apoptotic effect in serum-deprived RGC-5 cells and in the streptozotocin-induced diabetic rat retina. Methods: Apoptosis was quantified by activated caspase-3 immunohistochemistry or terminal dUTP nick end-labeling assay. Results: Nipradilol dose-dependently suppressed apoptosis in a protein kinase A- and G-dependent manner and counteracted glutamate-induced calcium entry in the RGC-5 cells and reduced apoptotic cells in the retinal ganglion cell layer of 4- and 12-week diabetic retinas compared to controls when instilled for 5 days. Removal of the nitric oxide moiety from nipradilol blocked these effects. Conclusions: Nipradilol protects RGCs from apoptosis induced by serum-deprivation in vitro and by diabetes in vivo. The NO-related signaling pathway mediates the anti-apoptotic ability of nipradilol." @default.
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- W1988978696 date "2008-01-01" @default.
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- W1988978696 title "Nipradilol Protects Rat Retinal Ganglion Cells from Apoptosis Induced by Serum DeprivationIn Vitroand by DiabetesIn Vivo" @default.
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- W1988978696 doi "https://doi.org/10.1080/02713680802323157" @default.
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