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• W1988985087 abstract "No information has been available on the acute hepatotoxic effects of N-nitrosopyrrolidine (NPY), a hepatocarcinogenic nitrosamine. 24 h after a single dose of 100 mg/kg, centrilobular fatty change and inflammatory cell infiltrate occurred. There was no cell necrosis. Cytochemically the centrilobular and mid-zonal areas showed autophagy, reduction in lysosomes and depression of glucose-6-phosphatase. Less severe changes occurred after a single dose of 30 mg/kg and there were no detectable alterations after 10 mg/kg. Repeated daily injection of 100 or 30 mg/kg led to megalocytosis of hepatocytes after 6 doses. Because rats were unable to survive more than 7 doses of 100 mg/kg NPY, levels of 30, 10 or 3 mg/kg were administered daily for up to 12 weeks. By 8–12 weeks most hepatocytes in the centrilobular area were enlarged, and glucose-6-phosphatase activity was low. The lysosomal activity was variable; in some cells it resembled controls and in others there were few lysosomes scattered haphazardly throughout the hepatocyte. Cells with this low lysosomal activity at 12 weeks generally grouped in island-like areas and ultrastructurally were rich in SER. Only marginal changes were observed in rats given 3 mg/kg throughout this period. Periodic acid-Schiff (PAS) positive, iron-containing pigment filled the Kupffer cells in all rats treated for more than 6 days with 30 mg/kg. The hepatomegalocytes resemble those produced by pyrrolizidine alkaloids. This may imply an antimitotic effect similar to that exerted by NPY on primary rat kidney cells in culture." @default.
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• W1988985087 date "1977-09-01" @default.
• W1988985087 modified "2023-09-25" @default.
• W1988985087 title "Hepatotoxic response to single or repeated injections of N-nitrosopyrrolidine in the rat" @default.
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• W1988985087 doi "https://doi.org/10.1016/0009-2797(77)90017-5" @default.
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