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• W1988987675 endingPage "3339" @default.
• W1988987675 startingPage "3329" @default.
• W1988987675 abstract "The work aims to provide evidence on the viability of Lactobacillus spp. and a spore form of Bacillus subtilis from nonprocessed bacteria to coated dosage forms (i.e., mini-tablets, pellets, and their coated forms). Lactobacillus spp. were cultivated overnight in MRS broth (109 cfu/mL) and B. subtilis spores were produced on plate count agar (107 cfu/mL) for 2 weeks. Bacteria and spores were freeze-dried in skim milk enriched with glycerol. The cakes were further processed into tablets (2.5 mm diameter) by direct compression with or without microcrystalline cellulose and inulin. Pellets (1–1.4 mm diameter) were produced by extrusion–spheronization of bacterial and spore suspensions with microcrystalline cellulose, lactose, inulin, and skim milk. Both tablets and pellets were film coated. The properties of the dosage forms, particularly the bacterial viability, were evaluated immediately after production and throughout storage for 6 months at 4°C. The study has shown that for an adequate stabilization of the bacteria a protective matrix (e.g., skim milk) and cryoprotectors (e.g., glycerol) must be present at early stages of bacterial de-hydration. Tabletting had a less deleterious effect (<2 log units) on bacteria when compared to pelletization (in some cases 3 log units). Enteric coating (15%, w/w) of either tablets or pellets did not affect the viability of the bacteria. © 2008 Wiley-Liss, Inc. and the American Pharmacists Association J Pharm Sci 98:3329–3339, 2009" @default.
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• W1988987675 date "2009-09-01" @default.
• W1988987675 modified "2023-09-26" @default.
• W1988987675 title "Evaluation of the viability of Lactobacillus spp. after the production of different solid dosage forms" @default.
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• W1988987675 doi "https://doi.org/10.1002/jps.21609" @default.
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