Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988993009> ?p ?o ?g. }
- W1988993009 endingPage "117.e11" @default.
- W1988993009 startingPage "117.e1" @default.
- W1988993009 abstract "The purpose of this study was to determine whether uteroplacental delivery of endotoxin produces fetal systemic and central nervous system reactions that are suggestive of inflammation.Lipopolysaccharide (30 or 60 microg) was administered into the uterine artery of late gestation (135 +/- 0.3 days) pregnant sheep. Fetal blood was assayed to determine changes in levels of quinolinic acid, which is a metabolite of tryptophan that is produced by monocytes (macrophages, microglia). Fetal brains were collected after 72 hours and examined for the presence of activated microglia and parenchymal macrophages.The brains of treated fetuses showed microglial activation and macrophage infiltration, which varied between brain region and lipopolysaccharide dose. Cell death that had been determined by cresyl violet/acid fuchsin staining was observed in the external capsule. There was significant increase of quinolinic acid in the fetal circulation, but no lipopolysaccharide was detected.Uteroplacental inflammation results in significant microglial activation and macrophage infiltration without direct fetal exposure to endotoxin, which suggests that placental responses contribute to perinatal brain damage that is associated with infection during pregnancy." @default.
- W1988993009 created "2016-06-24" @default.
- W1988993009 creator A5000320485 @default.
- W1988993009 creator A5023094909 @default.
- W1988993009 creator A5029226466 @default.
- W1988993009 creator A5087250475 @default.
- W1988993009 date "2008-01-01" @default.
- W1988993009 modified "2023-10-18" @default.
- W1988993009 title "Microglial activation, macrophage infiltration, and evidence of cell death in the fetal brain after uteroplacental administration of lipopolysaccharide in sheep in late gestation" @default.
- W1988993009 cites W1563043670 @default.
- W1988993009 cites W1753183749 @default.
- W1988993009 cites W1962177146 @default.
- W1988993009 cites W1967644902 @default.
- W1988993009 cites W1977765429 @default.
- W1988993009 cites W1985515495 @default.
- W1988993009 cites W1988810299 @default.
- W1988993009 cites W1988961665 @default.
- W1988993009 cites W1996591222 @default.
- W1988993009 cites W1997317484 @default.
- W1988993009 cites W2003710864 @default.
- W1988993009 cites W2008081306 @default.
- W1988993009 cites W2009874296 @default.
- W1988993009 cites W2012906643 @default.
- W1988993009 cites W2027158354 @default.
- W1988993009 cites W2058313314 @default.
- W1988993009 cites W2060689946 @default.
- W1988993009 cites W2068594676 @default.
- W1988993009 cites W2075463100 @default.
- W1988993009 cites W2076419133 @default.
- W1988993009 cites W2077745079 @default.
- W1988993009 cites W2082580274 @default.
- W1988993009 cites W2086517182 @default.
- W1988993009 cites W2089172549 @default.
- W1988993009 cites W2090859832 @default.
- W1988993009 cites W2094725377 @default.
- W1988993009 cites W2137207543 @default.
- W1988993009 cites W2158355439 @default.
- W1988993009 cites W2159746265 @default.
- W1988993009 cites W2337832923 @default.
- W1988993009 cites W2405280257 @default.
- W1988993009 cites W3100493246 @default.
- W1988993009 cites W4212867161 @default.
- W1988993009 cites W4232912614 @default.
- W1988993009 doi "https://doi.org/10.1016/j.ajog.2007.06.035" @default.
- W1988993009 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18166323" @default.
- W1988993009 hasPublicationYear "2008" @default.
- W1988993009 type Work @default.
- W1988993009 sameAs 1988993009 @default.
- W1988993009 citedByCount "48" @default.
- W1988993009 countsByYear W19889930092012 @default.
- W1988993009 countsByYear W19889930092013 @default.
- W1988993009 countsByYear W19889930092014 @default.
- W1988993009 countsByYear W19889930092015 @default.
- W1988993009 countsByYear W19889930092016 @default.
- W1988993009 countsByYear W19889930092017 @default.
- W1988993009 countsByYear W19889930092019 @default.
- W1988993009 countsByYear W19889930092020 @default.
- W1988993009 countsByYear W19889930092021 @default.
- W1988993009 crossrefType "journal-article" @default.
- W1988993009 hasAuthorship W1988993009A5000320485 @default.
- W1988993009 hasAuthorship W1988993009A5023094909 @default.
- W1988993009 hasAuthorship W1988993009A5029226466 @default.
- W1988993009 hasAuthorship W1988993009A5087250475 @default.
- W1988993009 hasConcept C121332964 @default.
- W1988993009 hasConcept C126322002 @default.
- W1988993009 hasConcept C134018914 @default.
- W1988993009 hasConcept C153400128 @default.
- W1988993009 hasConcept C172680121 @default.
- W1988993009 hasConcept C2776706248 @default.
- W1988993009 hasConcept C2776914184 @default.
- W1988993009 hasConcept C2777896816 @default.
- W1988993009 hasConcept C2778754761 @default.
- W1988993009 hasConcept C2779234561 @default.
- W1988993009 hasConcept C2779830541 @default.
- W1988993009 hasConcept C515207424 @default.
- W1988993009 hasConcept C529278444 @default.
- W1988993009 hasConcept C54355233 @default.
- W1988993009 hasConcept C55493867 @default.
- W1988993009 hasConcept C71924100 @default.
- W1988993009 hasConcept C86803240 @default.
- W1988993009 hasConcept C97355855 @default.
- W1988993009 hasConceptScore W1988993009C121332964 @default.
- W1988993009 hasConceptScore W1988993009C126322002 @default.
- W1988993009 hasConceptScore W1988993009C134018914 @default.
- W1988993009 hasConceptScore W1988993009C153400128 @default.
- W1988993009 hasConceptScore W1988993009C172680121 @default.
- W1988993009 hasConceptScore W1988993009C2776706248 @default.
- W1988993009 hasConceptScore W1988993009C2776914184 @default.
- W1988993009 hasConceptScore W1988993009C2777896816 @default.
- W1988993009 hasConceptScore W1988993009C2778754761 @default.
- W1988993009 hasConceptScore W1988993009C2779234561 @default.
- W1988993009 hasConceptScore W1988993009C2779830541 @default.
- W1988993009 hasConceptScore W1988993009C515207424 @default.
- W1988993009 hasConceptScore W1988993009C529278444 @default.
- W1988993009 hasConceptScore W1988993009C54355233 @default.
- W1988993009 hasConceptScore W1988993009C55493867 @default.
- W1988993009 hasConceptScore W1988993009C71924100 @default.
- W1988993009 hasConceptScore W1988993009C86803240 @default.