FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1988997130> ?p ?o ?g. }

• W1988997130 endingPage "1397" @default.
• W1988997130 startingPage "1390" @default.
• W1988997130 abstract "Interferon regulatory factor 3 (IRF-3) plays a crucial role in initiation and development of the IFN antiviral response. The expression level of human IRF-3 is thought to be closely related to antiviral state of cells. However, the mechanisms of the transcription regulation of IRF-3 have remained largely unknown. We previously reported that transcription factor E2F1 negatively regulates the basal transcriptional activity of IRF-3. Here we demonstrate that transcription factors Sp1 and Sp3 up-regulate the basal transcriptional activity of IRF-3 and increase IRF-3 expression at mRNA level. By transient transfection analysis we revealed that mutation of Sp1/NRF-1 binding site resulted in a profound reduction of IRF-3 promoter activity. Overexpression of Sp1 and Sp3, but not NRF-1, transactivated the IRF-3 promoter activity in reporter gene assays while knocking-down of endogenous Sp1 and Sp3 by a shRNA strategy markedly inhibited IRF-3 promoter activity. Chromatin immunoprecipitation (ChIP) assays showed that Sp1 and Sp3 interact with the IRF-3 promoter in vivo. These results suggest that basal expression level of IRF-3 is regulated by transcription factors Sp1 and Sp3." @default.
• W1988997130 created "2016-06-24" @default.
• W1988997130 creator A5018785155 @default.
• W1988997130 creator A5020478633 @default.
• W1988997130 creator A5040866586 @default.
• W1988997130 creator A5064871412 @default.
• W1988997130 creator A5064924352 @default.
• W1988997130 creator A5067814400 @default.
• W1988997130 date "2012-06-01" @default.
• W1988997130 modified "2023-10-18" @default.
• W1988997130 title "Transcription factors Sp1 and Sp3 regulate basal transcription of the human IRF-3 gene" @default.
• W1988997130 cites W1228798347 @default.
• W1988997130 cites W1970199385 @default.
• W1988997130 cites W1971082641 @default.
• W1988997130 cites W1982170462 @default.
• W1988997130 cites W1982828659 @default.
• W1988997130 cites W2001804120 @default.
• W1988997130 cites W2025405517 @default.
• W1988997130 cites W2028850807 @default.
• W1988997130 cites W2041233862 @default.
• W1988997130 cites W2054347191 @default.
• W1988997130 cites W2056970059 @default.
• W1988997130 cites W2062748949 @default.
• W1988997130 cites W2077291760 @default.
• W1988997130 cites W2083819673 @default.
• W1988997130 cites W2084880831 @default.
• W1988997130 cites W2085459501 @default.
• W1988997130 cites W2107324877 @default.
• W1988997130 cites W2147640266 @default.
• W1988997130 cites W2148896458 @default.
• W1988997130 cites W2162158991 @default.
• W1988997130 cites W99207100 @default.
• W1988997130 doi "https://doi.org/10.1016/j.biochi.2012.03.011" @default.
• W1988997130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22464952" @default.
• W1988997130 hasPublicationYear "2012" @default.
• W1988997130 type Work @default.
• W1988997130 sameAs 1988997130 @default.
• W1988997130 citedByCount "15" @default.
• W1988997130 countsByYear W19889971302012 @default.
• W1988997130 countsByYear W19889971302013 @default.
• W1988997130 countsByYear W19889971302014 @default.
• W1988997130 countsByYear W19889971302016 @default.
• W1988997130 countsByYear W19889971302017 @default.
• W1988997130 countsByYear W19889971302018 @default.
• W1988997130 countsByYear W19889971302019 @default.
• W1988997130 countsByYear W19889971302020 @default.
• W1988997130 crossrefType "journal-article" @default.
• W1988997130 hasAuthorship W1988997130A5018785155 @default.
• W1988997130 hasAuthorship W1988997130A5020478633 @default.
• W1988997130 hasAuthorship W1988997130A5040866586 @default.
• W1988997130 hasAuthorship W1988997130A5064871412 @default.
• W1988997130 hasAuthorship W1988997130A5064924352 @default.
• W1988997130 hasAuthorship W1988997130A5067814400 @default.
• W1988997130 hasConcept C101762097 @default.
• W1988997130 hasConcept C104317684 @default.
• W1988997130 hasConcept C132376346 @default.
• W1988997130 hasConcept C134320426 @default.
• W1988997130 hasConcept C138885662 @default.
• W1988997130 hasConcept C144825837 @default.
• W1988997130 hasConcept C150194340 @default.
• W1988997130 hasConcept C153911025 @default.
• W1988997130 hasConcept C179926584 @default.
• W1988997130 hasConcept C191163429 @default.
• W1988997130 hasConcept C27153228 @default.
• W1988997130 hasConcept C41895202 @default.
• W1988997130 hasConcept C54355233 @default.
• W1988997130 hasConcept C57467964 @default.
• W1988997130 hasConcept C76753757 @default.
• W1988997130 hasConcept C86339819 @default.
• W1988997130 hasConcept C86803240 @default.
• W1988997130 hasConcept C9173399 @default.
• W1988997130 hasConceptScore W1988997130C101762097 @default.
• W1988997130 hasConceptScore W1988997130C104317684 @default.
• W1988997130 hasConceptScore W1988997130C132376346 @default.
• W1988997130 hasConceptScore W1988997130C134320426 @default.
• W1988997130 hasConceptScore W1988997130C138885662 @default.
• W1988997130 hasConceptScore W1988997130C144825837 @default.
• W1988997130 hasConceptScore W1988997130C150194340 @default.
• W1988997130 hasConceptScore W1988997130C153911025 @default.
• W1988997130 hasConceptScore W1988997130C179926584 @default.
• W1988997130 hasConceptScore W1988997130C191163429 @default.
• W1988997130 hasConceptScore W1988997130C27153228 @default.
• W1988997130 hasConceptScore W1988997130C41895202 @default.
• W1988997130 hasConceptScore W1988997130C54355233 @default.
• W1988997130 hasConceptScore W1988997130C57467964 @default.
• W1988997130 hasConceptScore W1988997130C76753757 @default.
• W1988997130 hasConceptScore W1988997130C86339819 @default.
• W1988997130 hasConceptScore W1988997130C86803240 @default.
• W1988997130 hasConceptScore W1988997130C9173399 @default.
• W1988997130 hasFunder F4320321001 @default.
• W1988997130 hasIssue "6" @default.
• W1988997130 hasLocation W19889971301 @default.
• W1988997130 hasLocation W19889971302 @default.
• W1988997130 hasOpenAccess W1988997130 @default.
• W1988997130 hasPrimaryLocation W19889971301 @default.
• W1988997130 hasRelatedWork W1963981548 @default.
• W1988997130 hasRelatedWork W1977032243 @default.
• W1988997130 hasRelatedWork W1988997130 @default.

• next