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- W1989013872 abstract "The bilateral administration of 6-hydroxydopamine into the caudatus-putamen areas of the rat decreased the analgesia produced by morphine and the brain's content of dopamine in a dose-dependent fashion and increased morphine-induced catalepsy. The administration of l-DOPA with Ro 4-4602, a peripheral decarboxylase inhibitor, restored the analgesia but enhanced the catalepsy. The compounds also caused a marked elevation of the brain concentration of dopamine. Treatment of normal rats with l-DOPA plus Ro 4-4602 decreased analgesia in a dose-dependent fashion, enhanced catalepsy and increased the brain's content of dopamine." @default.
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- W1989013872 date "1973-12-01" @default.
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- W1989013872 title "Decrease in morphine's analgesic action and increase in its cataleptic action by 6-hydroxydopamine injected bilaterally into caudate and putamen areas; partial restoration by l-DOPA plus decarboxylase inhibition" @default.
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- W1989013872 doi "https://doi.org/10.1016/0028-3908(73)90072-5" @default.
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