FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989014719> ?p ?o ?g. }

• W1989014719 endingPage "3414" @default.
• W1989014719 startingPage "3410" @default.
• W1989014719 abstract "We have used boron-based molecules to create novel, competitive, reversible inhibitors of phosphodiesterase 4 (PDE4). The co-crystal structure reveals a binding configuration which is unique compared to classical catechol PDE4 inhibitors, with boron binding to the activated water in the bimetal center. These phenoxybenzoxaboroles can be optimized to generate submicromolar potency enzyme inhibitors, which inhibit TNF-α, IL-2, IFN-γ, IL-5 and IL-10 activities in vitro and show safety and efficacy for topical treatment of human psoriasis. They provide a valuable new route for creating novel potent anti-PDE4 inhibitors." @default.
• W1989014719 created "2016-06-24" @default.
• W1989014719 creator A5005714176 @default.
• W1989014719 creator A5012093464 @default.
• W1989014719 creator A5023994204 @default.
• W1989014719 creator A5031871633 @default.
• W1989014719 creator A5032544502 @default.
• W1989014719 creator A5032897212 @default.
• W1989014719 creator A5033601718 @default.
• W1989014719 creator A5033949696 @default.
• W1989014719 creator A5038083349 @default.
• W1989014719 creator A5055302959 @default.
• W1989014719 creator A5055515061 @default.
• W1989014719 creator A5060645166 @default.
• W1989014719 creator A5089200254 @default.
• W1989014719 creator A5090764727 @default.
• W1989014719 creator A5091001053 @default.
• W1989014719 date "2012-07-25" @default.
• W1989014719 modified "2023-10-16" @default.
• W1989014719 title "Boron-based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center" @default.
• W1989014719 cites W1970882309 @default.
• W1989014719 cites W1971574036 @default.
• W1989014719 cites W2000840258 @default.
• W1989014719 cites W2041669657 @default.
• W1989014719 cites W2082518700 @default.
• W1989014719 cites W2089432886 @default.
• W1989014719 cites W2104479866 @default.
• W1989014719 cites W2110524202 @default.
• W1989014719 cites W2118462346 @default.
• W1989014719 cites W2123066014 @default.
• W1989014719 cites W2151783961 @default.
• W1989014719 cites W2154558722 @default.
• W1989014719 cites W61054095 @default.
• W1989014719 doi "https://doi.org/10.1016/j.febslet.2012.07.058" @default.
• W1989014719 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22841723" @default.
• W1989014719 hasPublicationYear "2012" @default.
• W1989014719 type Work @default.
• W1989014719 sameAs 1989014719 @default.
• W1989014719 citedByCount "83" @default.
• W1989014719 countsByYear W19890147192013 @default.
• W1989014719 countsByYear W19890147192014 @default.
• W1989014719 countsByYear W19890147192015 @default.
• W1989014719 countsByYear W19890147192016 @default.
• W1989014719 countsByYear W19890147192017 @default.
• W1989014719 countsByYear W19890147192018 @default.
• W1989014719 countsByYear W19890147192019 @default.
• W1989014719 countsByYear W19890147192020 @default.
• W1989014719 countsByYear W19890147192021 @default.
• W1989014719 countsByYear W19890147192022 @default.
• W1989014719 countsByYear W19890147192023 @default.
• W1989014719 crossrefType "journal-article" @default.
• W1989014719 hasAuthorship W1989014719A5005714176 @default.
• W1989014719 hasAuthorship W1989014719A5012093464 @default.
• W1989014719 hasAuthorship W1989014719A5023994204 @default.
• W1989014719 hasAuthorship W1989014719A5031871633 @default.
• W1989014719 hasAuthorship W1989014719A5032544502 @default.
• W1989014719 hasAuthorship W1989014719A5032897212 @default.
• W1989014719 hasAuthorship W1989014719A5033601718 @default.
• W1989014719 hasAuthorship W1989014719A5033949696 @default.
• W1989014719 hasAuthorship W1989014719A5038083349 @default.
• W1989014719 hasAuthorship W1989014719A5055302959 @default.
• W1989014719 hasAuthorship W1989014719A5055515061 @default.
• W1989014719 hasAuthorship W1989014719A5060645166 @default.
• W1989014719 hasAuthorship W1989014719A5089200254 @default.
• W1989014719 hasAuthorship W1989014719A5090764727 @default.
• W1989014719 hasAuthorship W1989014719A5091001053 @default.
• W1989014719 hasBestOaLocation W19890147191 @default.
• W1989014719 hasConcept C147789679 @default.
• W1989014719 hasConcept C181199279 @default.
• W1989014719 hasConcept C185592680 @default.
• W1989014719 hasConcept C202751555 @default.
• W1989014719 hasConcept C21951064 @default.
• W1989014719 hasConcept C2777713698 @default.
• W1989014719 hasConcept C55493867 @default.
• W1989014719 hasConcept C62826618 @default.
• W1989014719 hasConcept C74793105 @default.
• W1989014719 hasConceptScore W1989014719C147789679 @default.
• W1989014719 hasConceptScore W1989014719C181199279 @default.
• W1989014719 hasConceptScore W1989014719C185592680 @default.
• W1989014719 hasConceptScore W1989014719C202751555 @default.
• W1989014719 hasConceptScore W1989014719C21951064 @default.
• W1989014719 hasConceptScore W1989014719C2777713698 @default.
• W1989014719 hasConceptScore W1989014719C55493867 @default.
• W1989014719 hasConceptScore W1989014719C62826618 @default.
• W1989014719 hasConceptScore W1989014719C74793105 @default.
• W1989014719 hasIssue "19" @default.
• W1989014719 hasLocation W19890147191 @default.
• W1989014719 hasLocation W19890147192 @default.
• W1989014719 hasLocation W19890147193 @default.
• W1989014719 hasOpenAccess W1989014719 @default.
• W1989014719 hasPrimaryLocation W19890147191 @default.
• W1989014719 hasRelatedWork W1581350964 @default.
• W1989014719 hasRelatedWork W2038246362 @default.
• W1989014719 hasRelatedWork W2081527906 @default.
• W1989014719 hasRelatedWork W2163398121 @default.
• W1989014719 hasRelatedWork W2314145514 @default.
• W1989014719 hasRelatedWork W2950786478 @default.
• W1989014719 hasRelatedWork W2951015813 @default.

• next