Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989025392> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1989025392 endingPage "586" @default.
- W1989025392 startingPage "583" @default.
- W1989025392 abstract "Because reoxygenation of solid tumors after irradiation with a hypoxic cell sensitizer has never previously been investigated, we assessed the reoxygenation in SCCVII tumors after treatment with KU-2285 plus single or fractionated irradiation.KU-2285 (100 mg/kg) was injected intraperitoneally into C3H mice bearing 1-cm SCCVII tumors at 30 min before a single dose of 12 Gy or three fractions of 5 Gy at 12 h intervals. Changes of the hypoxic fraction (HF) were then evaluated by the paired survival curve method.Since the radiosensitizing effect of KU-2285 was relatively persistent, the HF was only evaluable after 6 h of irradiation. The HF of untreated SCCVII tumors was 9.1%. After treatment with KU-2285 and 12 Gy, the HF was 25% at 6 h, 32% at 12 h, 24% at 24 h, and 7.6% at 72 h. The HF was lower at 6 h than that after radiation alone, but was similar at later periods. After three fractions of 5 Gy with or without KU-2285, the HF was 33% at 6 h in both groups, while it was 12% and 13% at 24 h for tumors pretreated with KU-2285 and those receiving radiation alone, respectively. However, a sensitizing effect of KU-2285 was indicated by the downward shift of the survival curves for tumors irradiated after exposure to this agent.Reoxygenation occurred quite efficiently in tumors receiving KU-2285 and 12 Gy. After fractionated irradiation, however, reoxygenation was similar in the KU-2285-pretreatment and irradiation alone groups." @default.
- W1989025392 created "2016-06-24" @default.
- W1989025392 creator A5013307791 @default.
- W1989025392 creator A5040691530 @default.
- W1989025392 creator A5050452238 @default.
- W1989025392 creator A5054458732 @default.
- W1989025392 creator A5066274607 @default.
- W1989025392 creator A5071240286 @default.
- W1989025392 creator A5078435301 @default.
- W1989025392 creator A5081170796 @default.
- W1989025392 date "1994-06-01" @default.
- W1989025392 modified "2023-10-16" @default.
- W1989025392 title "Reoxygenation in the SCCVII tumor after KU-2285 sensitization plus single or fractionated irradiation" @default.
- W1989025392 cites W1982285820 @default.
- W1989025392 cites W1993642626 @default.
- W1989025392 cites W1994555849 @default.
- W1989025392 cites W2059232606 @default.
- W1989025392 cites W2066082960 @default.
- W1989025392 cites W2090392139 @default.
- W1989025392 cites W2106935361 @default.
- W1989025392 cites W2136786497 @default.
- W1989025392 cites W2167229055 @default.
- W1989025392 doi "https://doi.org/10.1016/0360-3016(94)90461-8" @default.
- W1989025392 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8005819" @default.
- W1989025392 hasPublicationYear "1994" @default.
- W1989025392 type Work @default.
- W1989025392 sameAs 1989025392 @default.
- W1989025392 citedByCount "16" @default.
- W1989025392 countsByYear W19890253922012 @default.
- W1989025392 countsByYear W19890253922013 @default.
- W1989025392 countsByYear W19890253922014 @default.
- W1989025392 countsByYear W19890253922015 @default.
- W1989025392 countsByYear W19890253922023 @default.
- W1989025392 crossrefType "journal-article" @default.
- W1989025392 hasAuthorship W1989025392A5013307791 @default.
- W1989025392 hasAuthorship W1989025392A5040691530 @default.
- W1989025392 hasAuthorship W1989025392A5050452238 @default.
- W1989025392 hasAuthorship W1989025392A5054458732 @default.
- W1989025392 hasAuthorship W1989025392A5066274607 @default.
- W1989025392 hasAuthorship W1989025392A5071240286 @default.
- W1989025392 hasAuthorship W1989025392A5078435301 @default.
- W1989025392 hasAuthorship W1989025392A5081170796 @default.
- W1989025392 hasConcept C111337013 @default.
- W1989025392 hasConcept C121332964 @default.
- W1989025392 hasConcept C141071460 @default.
- W1989025392 hasConcept C185544564 @default.
- W1989025392 hasConcept C2989005 @default.
- W1989025392 hasConcept C509974204 @default.
- W1989025392 hasConcept C71924100 @default.
- W1989025392 hasConceptScore W1989025392C111337013 @default.
- W1989025392 hasConceptScore W1989025392C121332964 @default.
- W1989025392 hasConceptScore W1989025392C141071460 @default.
- W1989025392 hasConceptScore W1989025392C185544564 @default.
- W1989025392 hasConceptScore W1989025392C2989005 @default.
- W1989025392 hasConceptScore W1989025392C509974204 @default.
- W1989025392 hasConceptScore W1989025392C71924100 @default.
- W1989025392 hasIssue "3" @default.
- W1989025392 hasLocation W19890253921 @default.
- W1989025392 hasLocation W19890253922 @default.
- W1989025392 hasOpenAccess W1989025392 @default.
- W1989025392 hasPrimaryLocation W19890253921 @default.
- W1989025392 hasRelatedWork W108213934 @default.
- W1989025392 hasRelatedWork W1995899133 @default.
- W1989025392 hasRelatedWork W2003855035 @default.
- W1989025392 hasRelatedWork W2272899425 @default.
- W1989025392 hasRelatedWork W2384708512 @default.
- W1989025392 hasRelatedWork W2473431470 @default.
- W1989025392 hasRelatedWork W3023315196 @default.
- W1989025392 hasRelatedWork W3029247339 @default.
- W1989025392 hasRelatedWork W3030916910 @default.
- W1989025392 hasRelatedWork W3153034825 @default.
- W1989025392 hasVolume "29" @default.
- W1989025392 isParatext "false" @default.
- W1989025392 isRetracted "false" @default.
- W1989025392 magId "1989025392" @default.
- W1989025392 workType "article" @default.