Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989031118> ?p ?o ?g. }
- W1989031118 endingPage "1670" @default.
- W1989031118 startingPage "1643" @default.
- W1989031118 abstract "Iron-chelation therapy has its origins in the treatment of iron-overload syndromes. For many years, the standard for this purpose has been deferoxamine. Recently, considerable progress has been made in identifying synthetic chelators with improved pharmacologic properties relative to deferoxamine. Most notable are deferasirox (Exjade ® ) and deferiprone (Ferriprox ® ), which are now available clinically. In addition to treatment of iron overload, there is an emerging role for iron chelators in the treatment of diseases characterized by oxidative stress, including cardiovascular disease, atherosclerosis, neurodegenerative diseases and cancer. While iron is not regarded as the underlying cause of these diseases, it does play an important role in disease progression, either through promotion of cellular growth and proliferation or through participation in redox reactions that catalyze the formation of reactive oxygen species and increase oxidative stress. Thus, iron chelators may be of therapeutic benefit in many of these conditions. Phytochemicals, many of which bind iron, may also owe some of their beneficial properties to iron chelation. This review will focus on the advances in iron-chelation therapy for the treatment of iron-overload disease and cancer, as well as neurodegenerative and chronic inflammatory diseases. Established and novel iron chelators will be discussed, as well as the emerging role of dietary plant polyphenols that effectively modulate iron biochemistry." @default.
- W1989031118 created "2016-06-24" @default.
- W1989031118 creator A5059036012 @default.
- W1989031118 creator A5082037761 @default.
- W1989031118 creator A5087773842 @default.
- W1989031118 creator A5091029117 @default.
- W1989031118 date "2009-12-01" @default.
- W1989031118 modified "2023-10-12" @default.
- W1989031118 title "Synthetic and natural iron chelators: therapeutic potential and clinical use" @default.
- W1989031118 cites W112686769 @default.
- W1989031118 cites W116663061 @default.
- W1989031118 cites W140443178 @default.
- W1989031118 cites W1488760471 @default.
- W1989031118 cites W1504634754 @default.
- W1989031118 cites W1531142686 @default.
- W1989031118 cites W1568628619 @default.
- W1989031118 cites W1568912715 @default.
- W1989031118 cites W1618001767 @default.
- W1989031118 cites W1637392459 @default.
- W1989031118 cites W1681816121 @default.
- W1989031118 cites W169275994 @default.
- W1989031118 cites W1734082729 @default.
- W1989031118 cites W1751677383 @default.
- W1989031118 cites W1868361743 @default.
- W1989031118 cites W1879184430 @default.
- W1989031118 cites W1888348506 @default.
- W1989031118 cites W1904461647 @default.
- W1989031118 cites W1931225762 @default.
- W1989031118 cites W1939387286 @default.
- W1989031118 cites W1949685274 @default.
- W1989031118 cites W1954055116 @default.
- W1989031118 cites W1966590203 @default.
- W1989031118 cites W1966955741 @default.
- W1989031118 cites W1967648231 @default.
- W1989031118 cites W1968559867 @default.
- W1989031118 cites W1968666031 @default.
- W1989031118 cites W1969296748 @default.
- W1989031118 cites W1969863703 @default.
- W1989031118 cites W1971005475 @default.
- W1989031118 cites W1972422447 @default.
- W1989031118 cites W1972647898 @default.
- W1989031118 cites W1972856320 @default.
- W1989031118 cites W1975618852 @default.
- W1989031118 cites W1976752241 @default.
- W1989031118 cites W1976937900 @default.
- W1989031118 cites W1977373583 @default.
- W1989031118 cites W1978071562 @default.
- W1989031118 cites W1978774658 @default.
- W1989031118 cites W1980042430 @default.
- W1989031118 cites W1980459953 @default.
- W1989031118 cites W1981727187 @default.
- W1989031118 cites W1982224986 @default.
- W1989031118 cites W1982930928 @default.
- W1989031118 cites W1984171890 @default.
- W1989031118 cites W1985498851 @default.
- W1989031118 cites W1987113388 @default.
- W1989031118 cites W1988006868 @default.
- W1989031118 cites W1990841686 @default.
- W1989031118 cites W1992451200 @default.
- W1989031118 cites W1994166804 @default.
- W1989031118 cites W1994554510 @default.
- W1989031118 cites W1995366948 @default.
- W1989031118 cites W1997149430 @default.
- W1989031118 cites W1998649217 @default.
- W1989031118 cites W2000302463 @default.
- W1989031118 cites W2000967440 @default.
- W1989031118 cites W2002176182 @default.
- W1989031118 cites W2003835077 @default.
- W1989031118 cites W2004285067 @default.
- W1989031118 cites W2005223680 @default.
- W1989031118 cites W2005459756 @default.
- W1989031118 cites W2005883397 @default.
- W1989031118 cites W2005904261 @default.
- W1989031118 cites W2005952102 @default.
- W1989031118 cites W2006250045 @default.
- W1989031118 cites W2006358233 @default.
- W1989031118 cites W2006493859 @default.
- W1989031118 cites W2007340372 @default.
- W1989031118 cites W2007680457 @default.
- W1989031118 cites W2008744726 @default.
- W1989031118 cites W2009254906 @default.
- W1989031118 cites W2011657572 @default.
- W1989031118 cites W2012466213 @default.
- W1989031118 cites W2012960949 @default.
- W1989031118 cites W2015112433 @default.
- W1989031118 cites W2015248217 @default.
- W1989031118 cites W2016012939 @default.
- W1989031118 cites W2016333172 @default.
- W1989031118 cites W2016762050 @default.
- W1989031118 cites W2017423773 @default.
- W1989031118 cites W2017963754 @default.
- W1989031118 cites W2018974184 @default.
- W1989031118 cites W2019133295 @default.
- W1989031118 cites W2021711019 @default.
- W1989031118 cites W2024450406 @default.
- W1989031118 cites W2025996143 @default.
- W1989031118 cites W2026690848 @default.
- W1989031118 cites W2027201318 @default.