Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989035148> ?p ?o ?g. }
- W1989035148 endingPage "8278" @default.
- W1989035148 startingPage "8269" @default.
- W1989035148 abstract "Treatment of the disrupted digital flexor tendon is troublesome because of the lack of sufficient healing capacity and the formation of adhesions. Sustained gene delivery may be a promising approach of modulating gene expression in enhancing tendon healing and decreasing adhesions. In this study, a microRNA-based RNAi plasmid was used to specifically silence the expression of TGF-β1 gene associated with scar and adhesion formation in the flexor tendons. The miRNA plasmids were complexed with polylactic-co-glycolic acid (PLGA) nanoparticles to form nanoparticle/TGF-β1 miRNA plasmid (nanoparticle/plasmid) complexes. In vitro and in vivo transfection efficiencies experiments against tenocytes revealed that nanoparticle/plasmid complexes have significantly superior transfection efficiency over the lipofectamine/plasmid complexes. The gene and protein expression associated with adhesion of tendon treated with nanoparticle/plasmid complexes were evaluated by real-time PCR and immunoblotting. The grading of adhesions for tendons treated with nanoparticle/plasmid complexes was less severe than that treated with the nanoparticle/mock plasmid complexes. However, the ultimate strength of repaired tendons treated with nanoparticle/plasmid complexes was significantly lower than that of tendons treated with the nanoparticle/mock plasmid complexes." @default.
- W1989035148 created "2016-06-24" @default.
- W1989035148 creator A5000414137 @default.
- W1989035148 creator A5026050036 @default.
- W1989035148 creator A5040596844 @default.
- W1989035148 creator A5044528240 @default.
- W1989035148 creator A5073808829 @default.
- W1989035148 creator A5088989949 @default.
- W1989035148 date "2013-11-01" @default.
- W1989035148 modified "2023-10-14" @default.
- W1989035148 title "Nanoparticle-mediated delivery of TGF-β1 miRNA plasmid for preventing flexor tendon adhesion formation" @default.
- W1989035148 cites W1564553363 @default.
- W1989035148 cites W1963554792 @default.
- W1989035148 cites W1967265958 @default.
- W1989035148 cites W1970091519 @default.
- W1989035148 cites W1976175169 @default.
- W1989035148 cites W1980867086 @default.
- W1989035148 cites W1981233223 @default.
- W1989035148 cites W1991613206 @default.
- W1989035148 cites W2003104864 @default.
- W1989035148 cites W2010873143 @default.
- W1989035148 cites W2012026968 @default.
- W1989035148 cites W2015891619 @default.
- W1989035148 cites W2016195406 @default.
- W1989035148 cites W2016272919 @default.
- W1989035148 cites W2020397865 @default.
- W1989035148 cites W2037236265 @default.
- W1989035148 cites W2047512655 @default.
- W1989035148 cites W2048676159 @default.
- W1989035148 cites W2050662418 @default.
- W1989035148 cites W2053441129 @default.
- W1989035148 cites W2055864043 @default.
- W1989035148 cites W2056837339 @default.
- W1989035148 cites W2058146482 @default.
- W1989035148 cites W2061638146 @default.
- W1989035148 cites W2070008475 @default.
- W1989035148 cites W2078302554 @default.
- W1989035148 cites W2079793032 @default.
- W1989035148 cites W2082653146 @default.
- W1989035148 cites W2088718561 @default.
- W1989035148 cites W2089773350 @default.
- W1989035148 cites W2105345108 @default.
- W1989035148 cites W2120002085 @default.
- W1989035148 cites W2139784287 @default.
- W1989035148 cites W2142249617 @default.
- W1989035148 cites W2165237388 @default.
- W1989035148 cites W2321682041 @default.
- W1989035148 cites W2331665565 @default.
- W1989035148 cites W2333540186 @default.
- W1989035148 cites W2408776107 @default.
- W1989035148 doi "https://doi.org/10.1016/j.biomaterials.2013.07.072" @default.
- W1989035148 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23924908" @default.
- W1989035148 hasPublicationYear "2013" @default.
- W1989035148 type Work @default.
- W1989035148 sameAs 1989035148 @default.
- W1989035148 citedByCount "86" @default.
- W1989035148 countsByYear W19890351482014 @default.
- W1989035148 countsByYear W19890351482015 @default.
- W1989035148 countsByYear W19890351482016 @default.
- W1989035148 countsByYear W19890351482017 @default.
- W1989035148 countsByYear W19890351482018 @default.
- W1989035148 countsByYear W19890351482019 @default.
- W1989035148 countsByYear W19890351482020 @default.
- W1989035148 countsByYear W19890351482021 @default.
- W1989035148 countsByYear W19890351482022 @default.
- W1989035148 countsByYear W19890351482023 @default.
- W1989035148 crossrefType "journal-article" @default.
- W1989035148 hasAuthorship W1989035148A5000414137 @default.
- W1989035148 hasAuthorship W1989035148A5026050036 @default.
- W1989035148 hasAuthorship W1989035148A5040596844 @default.
- W1989035148 hasAuthorship W1989035148A5044528240 @default.
- W1989035148 hasAuthorship W1989035148A5073808829 @default.
- W1989035148 hasAuthorship W1989035148A5088989949 @default.
- W1989035148 hasConcept C104317684 @default.
- W1989035148 hasConcept C111599444 @default.
- W1989035148 hasConcept C12554922 @default.
- W1989035148 hasConcept C135983454 @default.
- W1989035148 hasConcept C153911025 @default.
- W1989035148 hasConcept C155672457 @default.
- W1989035148 hasConcept C159985019 @default.
- W1989035148 hasConcept C171250308 @default.
- W1989035148 hasConcept C185592680 @default.
- W1989035148 hasConcept C192562407 @default.
- W1989035148 hasConcept C22744801 @default.
- W1989035148 hasConcept C2780165375 @default.
- W1989035148 hasConcept C40767141 @default.
- W1989035148 hasConcept C49923114 @default.
- W1989035148 hasConcept C54009773 @default.
- W1989035148 hasConcept C55493867 @default.
- W1989035148 hasConcept C84416704 @default.
- W1989035148 hasConcept C86803240 @default.
- W1989035148 hasConcept C92087593 @default.
- W1989035148 hasConcept C95444343 @default.
- W1989035148 hasConceptScore W1989035148C104317684 @default.
- W1989035148 hasConceptScore W1989035148C111599444 @default.
- W1989035148 hasConceptScore W1989035148C12554922 @default.
- W1989035148 hasConceptScore W1989035148C135983454 @default.
- W1989035148 hasConceptScore W1989035148C153911025 @default.