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- W1989047054 abstract "The functional status of glutathione, its related enzymes, and Cu,Zn-superoxide dismutase in colonocytes isolated from rats with trinitrobenzene sulphonic acid-induced colitis, and the effect of rebamipide (a scavenger) on these antioxidants and on colitis, were studied.The rats were treated with rebamipide, killed on day 14, and compared with controls. Glutathione and enzymatic activities were spectrophotometrically estimated. The effect of rebamipide on colitis was also assessed histologically and by myeloperoxidase activity.In controls the concentration of glutathione and the activities of glutathione S-transferase and Cu,Zn-superoxide dismutase were decreased, but that of glutathione peroxidase was increased. Rebamipide prevented the impairment of these enzymes, restored the concentration of glutathione, and attenuated (low damage scores and myeloperoxidase activity) the severity of the colitis.These features suggest that the impairment of antioxidants is closely related to the development of the inflammatory lesions, and rebamipide has a beneficial effect on experimental colitis." @default.
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- W1989047054 date "1996-01-01" @default.
- W1989047054 modified "2023-09-24" @default.
- W1989047054 title "Impairment of Antioxidants in Colonic Epithelial Cells Isolated from Trinitrobenzene Sulphonic Acid-Induced Colitis Rats Protective Effect of Rebamipide" @default.
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- W1989047054 doi "https://doi.org/10.3109/00365529609003118" @default.
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