FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989059601> ?p ?o ?g. }

• W1989059601 endingPage "3108" @default.
• W1989059601 startingPage "3098" @default.
• W1989059601 abstract "The Sox9 transcription factor plays an essential role in promoting chondrogenesis and regulating expression of chondrocyte extracellular-matrix genes. To identify genes that interact with Sox9 in promoting chondrocyte differentiation, we screened a cDNA library generated from the murine chondrogenic ATDC5 cell line to identify activators of the collagen, type II, α 1 (Col2a1) promoter. Here we have shown that paraspeckle regulatory protein 54-kDa nuclear RNA-binding protein (p54nrb) is an essential link between Sox9-regulated transcription and maturation of Sox9-target gene mRNA. We found that p54nrb physically interacted with Sox9 and enhanced Sox9-dependent transcriptional activation of the Col2a1 promoter. In ATDC5 cells, p54nrb colocalized with Sox9 protein in nuclear paraspeckle bodies, and knockdown of p54nrb suppressed Sox9-dependent Col2a1 expression and promoter activity. We generated a p54nrb mutant construct lacking RNA recognition motifs, and overexpression of mutant p54nrb in ATDC5 cells markedly altered the appearance of paraspeckle bodies and inhibited the maturation of Col2a1 mRNA. The mutant p54nrb inhibited chondrocyte differentiation of mesenchymal cells and mouse metatarsal explants. Furthermore, transgenic mice expressing the mutant p54nrb in the chondrocyte lineage exhibited dwarfism associated with impairment of chondrogenesis. These data suggest that p54nrb plays an important role in the regulation of Sox9 function and the formation of paraspeckle bodies during chondrogenesis." @default.
• W1989059601 created "2016-06-24" @default.
• W1989059601 creator A5017111711 @default.
• W1989059601 creator A5028445962 @default.
• W1989059601 creator A5044160632 @default.
• W1989059601 creator A5058409750 @default.
• W1989059601 creator A5061024866 @default.
• W1989059601 creator A5079099744 @default.
• W1989059601 creator A5081469161 @default.
• W1989059601 creator A5086021529 @default.
• W1989059601 creator A5087356195 @default.
• W1989059601 date "2008-09-02" @default.
• W1989059601 modified "2023-09-24" @default.
• W1989059601 title "Paraspeckle protein p54nrb links Sox9-mediated transcription with RNA processing during chondrogenesis in mice" @default.
• W1989059601 cites W1572306092 @default.
• W1989059601 cites W1574722884 @default.
• W1989059601 cites W1951293977 @default.
• W1989059601 cites W1963714463 @default.
• W1989059601 cites W1982565098 @default.
• W1989059601 cites W1988093620 @default.
• W1989059601 cites W1992668049 @default.
• W1989059601 cites W1997812904 @default.
• W1989059601 cites W2001546866 @default.
• W1989059601 cites W2005664674 @default.
• W1989059601 cites W2006543907 @default.
• W1989059601 cites W2008063990 @default.
• W1989059601 cites W2017288138 @default.
• W1989059601 cites W2028442510 @default.
• W1989059601 cites W2037217106 @default.
• W1989059601 cites W2042932723 @default.
• W1989059601 cites W2046080398 @default.
• W1989059601 cites W2060667756 @default.
• W1989059601 cites W2064366726 @default.
• W1989059601 cites W2064950265 @default.
• W1989059601 cites W2082886853 @default.
• W1989059601 cites W2087326548 @default.
• W1989059601 cites W2111108441 @default.
• W1989059601 cites W2114627554 @default.
• W1989059601 cites W2124792556 @default.
• W1989059601 cites W2127835108 @default.
• W1989059601 cites W2131445177 @default.
• W1989059601 cites W2150134228 @default.
• W1989059601 cites W2156726032 @default.
• W1989059601 cites W2159591573 @default.
• W1989059601 cites W2185015298 @default.
• W1989059601 cites W4254214228 @default.
• W1989059601 doi "https://doi.org/10.1172/jci31373" @default.
• W1989059601 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2491455" @default.
• W1989059601 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18677406" @default.
• W1989059601 hasPublicationYear "2008" @default.
• W1989059601 type Work @default.
• W1989059601 sameAs 1989059601 @default.
• W1989059601 citedByCount "73" @default.
• W1989059601 countsByYear W19890596012012 @default.
• W1989059601 countsByYear W19890596012013 @default.
• W1989059601 countsByYear W19890596012014 @default.
• W1989059601 countsByYear W19890596012015 @default.
• W1989059601 countsByYear W19890596012017 @default.
• W1989059601 countsByYear W19890596012018 @default.
• W1989059601 countsByYear W19890596012019 @default.
• W1989059601 countsByYear W19890596012020 @default.
• W1989059601 countsByYear W19890596012021 @default.
• W1989059601 countsByYear W19890596012022 @default.
• W1989059601 countsByYear W19890596012023 @default.
• W1989059601 crossrefType "journal-article" @default.
• W1989059601 hasAuthorship W1989059601A5017111711 @default.
• W1989059601 hasAuthorship W1989059601A5028445962 @default.
• W1989059601 hasAuthorship W1989059601A5044160632 @default.
• W1989059601 hasAuthorship W1989059601A5058409750 @default.
• W1989059601 hasAuthorship W1989059601A5061024866 @default.
• W1989059601 hasAuthorship W1989059601A5079099744 @default.
• W1989059601 hasAuthorship W1989059601A5081469161 @default.
• W1989059601 hasAuthorship W1989059601A5086021529 @default.
• W1989059601 hasAuthorship W1989059601A5087356195 @default.
• W1989059601 hasBestOaLocation W19890596011 @default.
• W1989059601 hasConcept C104317684 @default.
• W1989059601 hasConcept C105702510 @default.
• W1989059601 hasConcept C143065580 @default.
• W1989059601 hasConcept C153911025 @default.
• W1989059601 hasConcept C173396325 @default.
• W1989059601 hasConcept C185592680 @default.
• W1989059601 hasConcept C198826908 @default.
• W1989059601 hasConcept C2778486617 @default.
• W1989059601 hasConcept C2780550940 @default.
• W1989059601 hasConcept C2781403057 @default.
• W1989059601 hasConcept C35496256 @default.
• W1989059601 hasConcept C54355233 @default.
• W1989059601 hasConcept C86339819 @default.
• W1989059601 hasConcept C86803240 @default.
• W1989059601 hasConcept C95444343 @default.
• W1989059601 hasConceptScore W1989059601C104317684 @default.
• W1989059601 hasConceptScore W1989059601C105702510 @default.
• W1989059601 hasConceptScore W1989059601C143065580 @default.
• W1989059601 hasConceptScore W1989059601C153911025 @default.
• W1989059601 hasConceptScore W1989059601C173396325 @default.
• W1989059601 hasConceptScore W1989059601C185592680 @default.
• W1989059601 hasConceptScore W1989059601C198826908 @default.
• W1989059601 hasConceptScore W1989059601C2778486617 @default.

• next