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- W1989062816 abstract "Pregnant mice were given 50 mg/kg cocaine HCl (1% solution, sc) once daily from gestation days 7 through 18 (sperm positive = day 0; term = day 19). Pair-fed and untreated control groups were also used. The pregnant cocaine-treated females showed normal weight gain and food consumption but had significantly increased water consumption. The cocaine-treated group had a significant increase in embryonic resorptions but no significant effects on stillbirths or postnatal mortality. The offspring of cocaine-treated females had significantly reduced birth weights and postnatal weight gains up to the age of 28 days. There was also a delay in their ear opening but not in other maturational milestones. Increased water consumption following cocaine treatment has been reported by other studies. We speculate that cocaine has a diuretic effect. We discuss the implications of this effect during pregnancy." @default.
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- W1989062816 date "1992-09-01" @default.
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- W1989062816 title "Prenatal cocaine exposure in the laboratory mouse: Effects on maternal water consumption and offspring outcome" @default.
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- W1989062816 doi "https://doi.org/10.1016/0892-0362(92)90037-b" @default.
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