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- W1989063232 abstract "Our study identified Heligmosomoides polygyrus antigen factors with potential activity for regulation of T-cell proliferation and surviving of CD4+CD25−, CD4+CD25hi and CD3+CD8+ cell populations. The antiapoptotic activity of antigenic fractions separated by HPLC was evaluated in vitro after exposure of cells to DEX and rTNF-α. Different populations of cells responded to antigen fractions in distinct pattern; the most sensitive population of cells to H. polygyrus products were CD4+CD25hi after exposure to DEX and CD3+CD8+ T cells after exposure to rTNF-α. H. polygyrus antigens may influence survival of CD8+ T cells by regulation of c-FLIP rather than Bcl-2, which affects survival of CD4+CD25hi Treg cells and CD4+ T cells. Activation of NF-κB subunits, for example, p50 and p65 was essential for resistance of cells to apoptosis, and antigenic fractions F9 and F17 exerted different effect to F13. The most active fraction in inhibition of apoptosis was F9, which includes Hsp-60, calumenin, ferritin, galectin and thrombospondin. This study may provide new clues for recognition of factors that regulate the immune response during infection and which engage the TNF-α receptor-mediated and the mitochondria-mediated death pathway." @default.
- W1989063232 created "2016-06-24" @default.
- W1989063232 creator A5023025710 @default.
- W1989063232 creator A5024088681 @default.
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- W1989063232 date "2012-11-22" @default.
- W1989063232 modified "2023-09-23" @default.
- W1989063232 title "The antiapoptotic activity of<i>Heligmosomoides polygyrus</i>antigen fractions" @default.
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- W1989063232 doi "https://doi.org/10.1111/pim.12006" @default.
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