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- W1989080948 abstract "Fab fragments from antibodies directed against the subunits of E. coli RNA polymerase were prepared. They were used to study the inhibition of RNA synthesis and of DNA-binding. It was found that Fab fragments from antibodies against the β, β′, and σ subunit, and against holo enzyme, inhibit RNA synthesis, but to different extents, while anti α Fab fragments do not inhibit enzyme activity. DNA-binding is reduced only in the presence of anti σ and anti holo Fab fragments. The inhibition of RNA synthesis by anti σ Fab fragments can be neutralized if the enzyme is incubated with DNA before adding the Fab fragment. The anti β and anti β′ Fab fragments still inhibit the enzyme under these conditions. It is concluded that these Fab fragments directly inhibit the catalytic steps in RNA synthesis, whereas the inhibition by anti σ and anti holo Fab fragments originates from a reduced accessibility to the enzyme of the template in the presence of these Fab fragments." @default.
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- W1989080948 date "1981-05-01" @default.
- W1989080948 modified "2023-09-23" @default.
- W1989080948 title "Inhibition of E. coli RNA polymerase by Fab fragments from subunit specific antibodies" @default.
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- W1989080948 doi "https://doi.org/10.1016/s0006-291x(81)80082-4" @default.
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