FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989081010> ?p ?o ?g. }

• W1989081010 endingPage "1001" @default.
• W1989081010 startingPage "991" @default.
• W1989081010 abstract "Environmental polychlorinated biphenyls (PCBs) are frequently bound onto nanoparticles (NPs). However, the toxicity and health effects of PCBs assembled onto nanoparticles are unknown. The aim of this study was to study the hypothesis that binding PCBs to silica NPs potentiates PCB-induced cerebrovascular toxicity and brain damage in an experimental stroke model. Mice (C57BL/6, males, 12-week-old) were exposed to PCB153 bound to NPs (PCB153-NPs), PCB153, or vehicle. PCB153 was administered in the amount of 5 ng/g body weight. A group of treated animals was subjected to a 40 min ischemia, followed by a 24 h reperfusion. The blood–brain barrier (BBB) permeability, brain infarct volume, expression of tight junction (TJ) proteins, and inflammatory mediators were assessed. As compared to controls, a 24 h exposure to PCB153-NPs injected into cerebral vasculature resulted in significant elevation of the BBB permeability, disruption of TJ protein expression, increased proinflammatory responses, and enhanced monocyte transmigration in mouse brain capillaries. Importantly, exposure to PCB153-NPs increased stroke volume and potentiated brain damage in mice subjected to ischemia/reperfusion. A long-term (30 days) oral exposure to PCB153-NPs resulted in a higher PCB153 content in the abdominal adipose tissue and amplified adhesion of leukocytes to the brain endothelium as compared to treatment with PCB153 alone. This study provides the first evidence that binding to NPs increases cerebrovascular toxicity of environmental toxicants, such as PCB153." @default.
• W1989081010 created "2016-06-24" @default.
• W1989081010 creator A5010738468 @default.
• W1989081010 creator A5012144186 @default.
• W1989081010 creator A5046293802 @default.
• W1989081010 creator A5080248926 @default.
• W1989081010 creator A5080256378 @default.
• W1989081010 date "2012-10-19" @default.
• W1989081010 modified "2023-10-16" @default.
• W1989081010 title "Cerebrovascular Toxicity of PCB153 is Enhanced by Binding to Silica Nanoparticles" @default.
• W1989081010 cites W128185620 @default.
• W1989081010 cites W1548016685 @default.
• W1989081010 cites W1551592047 @default.
• W1989081010 cites W1624165018 @default.
• W1989081010 cites W1915763889 @default.
• W1989081010 cites W1968634197 @default.
• W1989081010 cites W1971203821 @default.
• W1989081010 cites W1972415054 @default.
• W1989081010 cites W1974572321 @default.
• W1989081010 cites W1989323349 @default.
• W1989081010 cites W1993749333 @default.
• W1989081010 cites W1998402312 @default.
• W1989081010 cites W2004063915 @default.
• W1989081010 cites W2010274527 @default.
• W1989081010 cites W2015541518 @default.
• W1989081010 cites W2017588114 @default.
• W1989081010 cites W2020915539 @default.
• W1989081010 cites W2022176011 @default.
• W1989081010 cites W2027154694 @default.
• W1989081010 cites W2027597717 @default.
• W1989081010 cites W2032898783 @default.
• W1989081010 cites W2035317723 @default.
• W1989081010 cites W2039864274 @default.
• W1989081010 cites W2043306265 @default.
• W1989081010 cites W2054010025 @default.
• W1989081010 cites W2062091008 @default.
• W1989081010 cites W2063164636 @default.
• W1989081010 cites W2064695457 @default.
• W1989081010 cites W2073327974 @default.
• W1989081010 cites W2073813648 @default.
• W1989081010 cites W2080600302 @default.
• W1989081010 cites W2080713749 @default.
• W1989081010 cites W2080877705 @default.
• W1989081010 cites W2082228411 @default.
• W1989081010 cites W2082640094 @default.
• W1989081010 cites W2097193479 @default.
• W1989081010 cites W2106025719 @default.
• W1989081010 cites W2106361045 @default.
• W1989081010 cites W2109162829 @default.
• W1989081010 cites W2115123250 @default.
• W1989081010 cites W2116080935 @default.
• W1989081010 cites W2128903550 @default.
• W1989081010 cites W2129852583 @default.
• W1989081010 cites W2130538711 @default.
• W1989081010 cites W2144960514 @default.
• W1989081010 cites W2148992136 @default.
• W1989081010 cites W2158430135 @default.
• W1989081010 cites W2167379393 @default.
• W1989081010 cites W2170632276 @default.
• W1989081010 cites W2792583460 @default.
• W1989081010 cites W2952513498 @default.
• W1989081010 doi "https://doi.org/10.1007/s11481-012-9403-y" @default.
• W1989081010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3518694" @default.
• W1989081010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23081707" @default.
• W1989081010 hasPublicationYear "2012" @default.
• W1989081010 type Work @default.
• W1989081010 sameAs 1989081010 @default.
• W1989081010 citedByCount "18" @default.
• W1989081010 countsByYear W19890810102013 @default.
• W1989081010 countsByYear W19890810102014 @default.
• W1989081010 countsByYear W19890810102015 @default.
• W1989081010 countsByYear W19890810102016 @default.
• W1989081010 countsByYear W19890810102017 @default.
• W1989081010 countsByYear W19890810102018 @default.
• W1989081010 countsByYear W19890810102019 @default.
• W1989081010 countsByYear W19890810102020 @default.
• W1989081010 countsByYear W19890810102021 @default.
• W1989081010 countsByYear W19890810102022 @default.
• W1989081010 countsByYear W19890810102023 @default.
• W1989081010 crossrefType "journal-article" @default.
• W1989081010 hasAuthorship W1989081010A5010738468 @default.
• W1989081010 hasAuthorship W1989081010A5012144186 @default.
• W1989081010 hasAuthorship W1989081010A5046293802 @default.
• W1989081010 hasAuthorship W1989081010A5080248926 @default.
• W1989081010 hasAuthorship W1989081010A5080256378 @default.
• W1989081010 hasBestOaLocation W19890810102 @default.
• W1989081010 hasConcept C116263406 @default.
• W1989081010 hasConcept C12554922 @default.
• W1989081010 hasConcept C126322002 @default.
• W1989081010 hasConcept C164027704 @default.
• W1989081010 hasConcept C177779419 @default.
• W1989081010 hasConcept C185592680 @default.
• W1989081010 hasConcept C2775962179 @default.
• W1989081010 hasConcept C2776914184 @default.
• W1989081010 hasConcept C2778402981 @default.
• W1989081010 hasConcept C29730261 @default.
• W1989081010 hasConcept C529278444 @default.
• W1989081010 hasConcept C55493867 @default.

• next