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• W1989096321 startingPage "1873" @default.
• W1989096321 abstract "An efficient method has been developed to synthesize casimiroin (1), a component of the edible fruit of Casimiroa edulis, on a multigram scale in good overall yield. The route was versatile enough to provide an array of compound 1 analogues that were evaluated as QR2 and aromatase inhibitors. In addition, X-ray crystallography studies of QR2 in complex with compound 1 and one of its more potent analogues has provided insight into the mechanism of action of this new series of QR2 inhibitors. The initial biological investigations suggest that compound 1 and its analogues merit further investigation as potential chemopreventive or chemotherapeutic agents." @default.
• W1989096321 created "2016-06-24" @default.
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• W1989096321 date "2009-03-06" @default.
• W1989096321 modified "2023-10-18" @default.
• W1989096321 title "Synthesis of Casimiroin and Optimization of Its Quinone Reductase 2 and Aromatase Inhibitory Activities" @default.
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• W1989096321 doi "https://doi.org/10.1021/jm801335z" @default.
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