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- W1989099003 abstract "Abstract Streptokinase activated human fibrinolysin (plasmin), chloroform activated bovine fibrinolysin, streptokinase, crystalline preparations of trypsin, chymotrypsin and papain inhibited CP, regardless by which of the mediators it was induced in guinea-pigs and rats. The mediators employed were histamine, serotonin and synthetic bradykinin. These findings were secured by the use of the rat's cremaster preparation of Majno and Palade, a qualitative test for CP, and with the blueing reaction, a semi-quantitative test for CP in the ventral regions of the skin, employing Evans blue in the anesthetized guinea-pig and rat. Concomitantly with the marked decrease in CP, petechial hemorrhages were produced demonstrating an increase of CF. These results provide evidence that CP and CF are antagonistic phenomena. This antagonism, as well as the inhibitory action if fibrinolysin and other proteolytic enzymes, can be explaind by Copley's modified concept of the endoendothelial fibrin film. This postulates a special fibrin, also contained in the BM, to be a cement of the capillary wall and fibrinolysis to control the integrity of the vessel wall." @default.
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- W1989099003 date "1962-06-01" @default.
- W1989099003 modified "2023-09-27" @default.
- W1989099003 title "Inhibitory action of fibrinolysin and other proteolytic enzymes on capillary permeability induced by histamine, serotonin and bradykinin" @default.
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- W1989099003 doi "https://doi.org/10.1016/0024-3205(62)90005-x" @default.
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