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- W1989102007 abstract "Furosemide improves lung mechanics in infants with bronchopul-monary dysplasia (BPD). However, in some infants we found that even if lung mechanics improve, PaCO2 rises and ventilation falls during furosemide therapy. Is this due to a furosemide-induced metabolic alkalosis with a secondary respiratory adjustment? Because the acid-base status of BPD patients is complex, we studied normal rabbit pups. For the first 9 days of life, 10 pups received intraperitoneal injections of furosemide (2mg/kg bid) and 10 pups received saline. On day 10, we inserted a catheter into one carotid artery and placed each pup in a plethysmograph. We measured body temperature; blood pressure; arterial gases and pH; serum Na, C1, K; respiratory frequency and tidal volume. We calculated ventilation (VE/g) and base excess (BE) and measured post-mortem static lung compliance (CL). Variables which were significantly different by unpaired t-test are shown below (means only, p<.05): Furosemide treated pups developed a primary alkalosis and a secondary respiratory acidosis; in addition, lung compliance was improved. KC1 injection to alkalotic pups increased VE and decreased pH. We conclude that furosemide 1) causes a metabolic alkalosis and reduces ventilation and 2) increases the PaCO2 which reflects changes in acid-base status and not changes in lung function." @default.
- W1989102007 created "2016-06-24" @default.
- W1989102007 creator A5081693305 @default.
- W1989102007 date "1984-04-01" @default.
- W1989102007 modified "2023-09-26" @default.
- W1989102007 title "FUROSEMIDE DECREASES VENTILATION IN NEWBORN RABBITS" @default.
- W1989102007 doi "https://doi.org/10.1203/00006450-198404001-01801" @default.
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