FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989121111> ?p ?o ?g. }

• W1989121111 endingPage "899" @default.
• W1989121111 startingPage "891" @default.
• W1989121111 abstract "Neurotensin (NT), a tridecapeptide that satisfies criteria as a neurotransmitter, mimics many actions of ethanol, and evidence indicates that some of the acute effects of ethanol are mediated in part by NT. Recent studies have shown that chronic ethanol treatment produced a downregulation of NT receptors in mesolimbic brain regions of long sleep (LS) mice and that reduced NT binding capacity was associated with acquisition and decay of tolerance to ethanol-induced locomotor inhibition and hypothermia in these mice. The present study was undertaken to determine whether cross-tolerance develops between NT and ethanol and whether chronic NT infusion produces NT receptor downregulation. Animals chronically treated with ethanol were tolerant to NT-mediated locomotor inhibition at a dose of 1.8 pmol NT, ICV, and were tolerant to NT-induced hypothermia at 1.8 and 6.0 pmol NT. Following repeated injections or continuous infusion of NT ICV, LS mice showed tolerance to both NT-and ethanol-induced hypothermia and locomotor inhibition. Indeed, ethanol doses that are hypnotic in control mice (2.8 g/ kg) were not effective in abolishing locomotor activity following chronic NT administration. Results with chronic saline infusion ICV indicate that stress alters sensitivity to ethanol-induced hypothermia. Chronic infusion of NT ICV produced a region-specific downregulation of high-affinity NT receptors in the striatum. The results demonstrate that cross-tolerance develops between NT and ethanol, and further support a role for neurotensinergic systems in the actions of ethanol." @default.
• W1989121111 created "2016-06-24" @default.
• W1989121111 creator A5009624627 @default.
• W1989121111 creator A5011925100 @default.
• W1989121111 creator A5029172289 @default.
• W1989121111 creator A5060901530 @default.
• W1989121111 date "1995-08-01" @default.
• W1989121111 modified "2023-10-18" @default.
• W1989121111 title "Cross-tolerance between ethanol and neurotensin in mice selectively bred for ethanol sensitivity" @default.
• W1989121111 cites W1676884362 @default.
• W1989121111 cites W1775749144 @default.
• W1989121111 cites W1972700598 @default.
• W1989121111 cites W1981967396 @default.
• W1989121111 cites W1986904760 @default.
• W1989121111 cites W1989228691 @default.
• W1989121111 cites W1995545889 @default.
• W1989121111 cites W1996660130 @default.
• W1989121111 cites W2000432617 @default.
• W1989121111 cites W2002114489 @default.
• W1989121111 cites W2012248604 @default.
• W1989121111 cites W2018495865 @default.
• W1989121111 cites W2020533417 @default.
• W1989121111 cites W2021738064 @default.
• W1989121111 cites W2023748625 @default.
• W1989121111 cites W2027773672 @default.
• W1989121111 cites W2031979379 @default.
• W1989121111 cites W2041110976 @default.
• W1989121111 cites W2042149310 @default.
• W1989121111 cites W2043589738 @default.
• W1989121111 cites W2054418838 @default.
• W1989121111 cites W2056269731 @default.
• W1989121111 cites W2062267409 @default.
• W1989121111 cites W2066850687 @default.
• W1989121111 cites W2071562996 @default.
• W1989121111 cites W2092968923 @default.
• W1989121111 cites W2093004374 @default.
• W1989121111 cites W2094436058 @default.
• W1989121111 cites W2311361070 @default.
• W1989121111 doi "https://doi.org/10.1016/0091-3057(95)00070-d" @default.
• W1989121111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7675874" @default.
• W1989121111 hasPublicationYear "1995" @default.
• W1989121111 type Work @default.
• W1989121111 sameAs 1989121111 @default.
• W1989121111 citedByCount "12" @default.
• W1989121111 countsByYear W19891211112013 @default.
• W1989121111 countsByYear W19891211112014 @default.
• W1989121111 countsByYear W19891211112018 @default.
• W1989121111 crossrefType "journal-article" @default.
• W1989121111 hasAuthorship W1989121111A5009624627 @default.
• W1989121111 hasAuthorship W1989121111A5011925100 @default.
• W1989121111 hasAuthorship W1989121111A5029172289 @default.
• W1989121111 hasAuthorship W1989121111A5060901530 @default.
• W1989121111 hasConcept C104317684 @default.
• W1989121111 hasConcept C118303440 @default.
• W1989121111 hasConcept C126322002 @default.
• W1989121111 hasConcept C127561419 @default.
• W1989121111 hasConcept C134018914 @default.
• W1989121111 hasConcept C170493617 @default.
• W1989121111 hasConcept C185592680 @default.
• W1989121111 hasConcept C2776219046 @default.
• W1989121111 hasConcept C2777389121 @default.
• W1989121111 hasConcept C2777390192 @default.
• W1989121111 hasConcept C2778195246 @default.
• W1989121111 hasConcept C2778976297 @default.
• W1989121111 hasConcept C2779985140 @default.
• W1989121111 hasConcept C2780062018 @default.
• W1989121111 hasConcept C2780161600 @default.
• W1989121111 hasConcept C2780930544 @default.
• W1989121111 hasConcept C513476851 @default.
• W1989121111 hasConcept C55493867 @default.
• W1989121111 hasConcept C71924100 @default.
• W1989121111 hasConcept C946728 @default.
• W1989121111 hasConcept C98274493 @default.
• W1989121111 hasConceptScore W1989121111C104317684 @default.
• W1989121111 hasConceptScore W1989121111C118303440 @default.
• W1989121111 hasConceptScore W1989121111C126322002 @default.
• W1989121111 hasConceptScore W1989121111C127561419 @default.
• W1989121111 hasConceptScore W1989121111C134018914 @default.
• W1989121111 hasConceptScore W1989121111C170493617 @default.
• W1989121111 hasConceptScore W1989121111C185592680 @default.
• W1989121111 hasConceptScore W1989121111C2776219046 @default.
• W1989121111 hasConceptScore W1989121111C2777389121 @default.
• W1989121111 hasConceptScore W1989121111C2777390192 @default.
• W1989121111 hasConceptScore W1989121111C2778195246 @default.
• W1989121111 hasConceptScore W1989121111C2778976297 @default.
• W1989121111 hasConceptScore W1989121111C2779985140 @default.
• W1989121111 hasConceptScore W1989121111C2780062018 @default.
• W1989121111 hasConceptScore W1989121111C2780161600 @default.
• W1989121111 hasConceptScore W1989121111C2780930544 @default.
• W1989121111 hasConceptScore W1989121111C513476851 @default.
• W1989121111 hasConceptScore W1989121111C55493867 @default.
• W1989121111 hasConceptScore W1989121111C71924100 @default.
• W1989121111 hasConceptScore W1989121111C946728 @default.
• W1989121111 hasConceptScore W1989121111C98274493 @default.
• W1989121111 hasIssue "4" @default.
• W1989121111 hasLocation W19891211111 @default.
• W1989121111 hasLocation W19891211112 @default.
• W1989121111 hasOpenAccess W1989121111 @default.

• next