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Matches in SemOpenAlex for { <https://semopenalex.org/work/W1989121125> ?p ?o ?g. }

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• W1989121125 abstract "The helicase portion of the hepatitis C virus nonstructural protein 3 (NS3) is considered one of the most validated targets for developing direct acting antiviral agents. We isolated polybrominated diphenyl ether (PBDE) 1 from a marine sponge as an NS3 helicase inhibitor. In this study, we evaluated the inhibitory effects of PBDE (1) on the essential activities of NS3 protein such as RNA helicase, ATPase, and RNA binding activities. The structure-activity relationship analysis of PBDE (1) against the HCV ATPase revealed that the biphenyl ring, bromine, and phenolic hydroxyl group on the benzene backbone might be a basic scaffold for the inhibitory potency." @default.
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• W1989121125 date "2014-04-02" @default.
• W1989121125 modified "2023-10-16" @default.
• W1989121125 title "PBDE: Structure-Activity Studies for the Inhibition of Hepatitis C Virus NS3 Helicase" @default.
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• W1989121125 doi "https://doi.org/10.3390/molecules19044006" @default.
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