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- W1989133066 abstract "Membrane-bounded organelles (MBOs) are delivered to different domains in neurons by fast axonal transport. The importance of kinesin for fast antero grade transport is well established, but mechanisms for regulating kinesin-based motility are largely unknown. In this report, we provide biochemical and in vivo evidence that kinesin light chains (KLCs) interact with and are in vivo substrates for glycogen synthase kinase 3 (GSK3). Active GSK3 inhibited anterograde, but not retrograde, transport in squid axoplasm and reduced the amount of kinesin bound to MBOs. Kinesin microtubule binding and microtubule-stimulated ATPase activities were unaffected by GSK3 phosphorylation of KLCs. Active GSK3 was also localized preferentially to regions known to be sites of membrane delivery. These data suggest that GSK3 can regulate fast anterograde axonal transport and targeting of cargos to specific subcellular domains in neurons." @default.
- W1989133066 created "2016-06-24" @default.
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- W1989133066 date "2002-02-01" @default.
- W1989133066 modified "2023-10-02" @default.
- W1989133066 title "Glycogen synthase kinase 3 phosphorylates kinesin light chains and negatively regulates kinesin-based motility" @default.
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- W1989133066 doi "https://doi.org/10.1093/emboj/21.3.281" @default.
- W1989133066 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/125832" @default.
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